Alterations in Functional Connectomics Associated With Neurocognitive Changes Following Glioma Resection
| العنوان: | Alterations in Functional Connectomics Associated With Neurocognitive Changes Following Glioma Resection |
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| المؤلفون: | Jeffrey S. Wefel, Ho Ling Liu, Sujit S. Prabhu, Henry S. Chen, Dima Suki, Ganesh Rao, Vinodh A. Kumar, Jason M. Johnson, Ping Hou, Kyle R. Noll, Sherise D. Ferguson, Donald F. Schomer |
| المصدر: | Neurosurgery |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, Oncology, medicine.medical_specialty, Connectomics, Verbal learning, Executive Function, 03 medical and health sciences, Cognition, 0302 clinical medicine, Memory, Internal medicine, Connectome, Humans, Medicine, Prospective Studies, Neuropsychological assessment, medicine.diagnostic_test, Brain Neoplasms, business.industry, Glioma, Middle Aged, Mental Status and Dementia Tests, Magnetic Resonance Imaging, Functional imaging, Research—Human—Clinical Studies, 030220 oncology & carcinogenesis, Female, Surgery, Neurology (clinical), Nerve Net, Verbal memory, business, Functional magnetic resonance imaging, Neurocognitive, Craniotomy, 030217 neurology & neurosurgery |
| الوصف: | BACKGROUND: Decline in neurocognitive functioning (NCF) often occurs following brain tumor resection. Functional connectomics have shown how neurologic insults disrupt cerebral networks underlying NCF, though studies involving patients with brain tumors are lacking. OBJECTIVE: To investigate the impact of brain tumor resection upon the connectome and relationships with NCF outcome in the early postoperative period. METHODS: A total of 15 right-handed adults with left perisylvian glioma underwent resting-state functional magnetic resonance imaging (rs-fMRI) and neuropsychological assessment before and after awake tumor resection. Graph theoretical analysis was applied to rs-fMRI connectivity matrices to calculate network properties. Network properties and NCF measures were compared across the pre- to postoperative periods with matched pairs Wilcoxon signed-rank tests. Associations between pre- to postoperative change in network and NCF measures were determined with Spearman rank-order correlations (ρ). RESULTS: A majority of the sample showed postoperative decline on 1 or more NCF measures. Significant postoperative NCF decline was found across measures of verbal memory, processing speed, executive functioning, receptive language, and a composite index. Regarding connectomic properties, betweenness centrality and assortativity were significantly smaller postoperatively, and reductions in these measures were associated with better NCF outcomes. Significant inverse associations (ρ = −.51 to −.78, all P |
| تدمد: | 1524-4040 0148-396X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23686f998b0cfe6bc5aff48b3182ad06Test https://doi.org/10.1093/neuros/nyaa453Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....23686f998b0cfe6bc5aff48b3182ad06 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244040 0148396X |
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