التفاصيل البيبلوغرافية
| العنوان: |
Neuroprotective effects of uridine in a rat model of neonatal hypoxic–ischemic encephalopathy. |
| المؤلفون: |
Cansev, Mehmet1, Minbay, Zehra2, Goren, Bulent3, Yaylagul, Esra Orenlili4, Cetinkaya, Merih5, Koksal, Nilgun5, Alkan, Tulin3 alkantulin@gmail.com |
| المصدر: |
Neuroscience Letters. May2013, Vol. 542, p65-70. 6p. |
| مصطلحات موضوعية: |
*NEUROPROTECTIVE agents, *URIDINE, *NEONATAL infections, *HEPATIC encephalopathy, *PYRIMIDINES, *NUCLEOTIDES, *PHOSPHOLIPIDS |
| مستخلص: |
Abstract: Neonatal hypoxic–ischemic encephalopathy (HIE) is a major cause of neurological disability requiring newer therapeutic strategies. Uridine is the principal circulating pyrimidine in humans and a substrate for nucleotides and membrane phospholipids. The objective of this study was to investigate the effects of uridine in a neonatal rat model of HIE. Rat pups subjected to hypoxic–ischemic insult on postnatal day 7 were injected intraperitoneally with either saline or uridine (100, 300 or 500mg/kg) for three consecutive days and brains were collected for evaluation of brain infarct volume and apoptosis. Compared with Control group, uridine at 300 and 500mg/kg doses significantly reduced percent infarct volume, TUNEL(+) cell ratio and active Caspase-3 immunoreactivity in the cortex, as well as in CA1 and CA3 regions of the hippocampus. Uridine (300 and 500mg/kg) also decreased active Caspase-3 expression in the ipsilateral hemisphere. These data indicate that uridine dose-dependently reduces brain injury in a rat model of neonatal HIE by decreasing apoptosis. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
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