المؤلفون: Jean-Marc Burgunder, M. Weber, Th Lauterburg, Irene Tobler

المصدر: Neuroscience Letters. 358:17-20

مصطلحات موضوعية: medicine.medical_specialty, Substantia nigra, Dynorphin, Motor Activity, Biology, Rats, Sprague-Dawley, Dopamine receptor D1, Dopamine, Dopamine receptor D2, Internal medicine, medicine, Animals, Neurotransmitter Agents, Tyrosine hydroxylase, General Neuroscience, Dopaminergic, Brain, Circadian Rhythm, Rats, Receptors, Neurotransmitter, Ventral tegmental area, Endocrinology, medicine.anatomical_structure, Gene Expression Regulation, Neuroscience, medicine.drug

الوصف: Mammalian motor activity displays circadian patterns in normal behaviour and in many movement disorders, like levodopa responsive dystonia and Parkinson's disease. Here, we hypothesized that a circadian pattern of dopamine synthesis would trigger rhythms in the expression of genes in regions receiving dopaminergic innervation. Indeed tyrosine hydroxylase and cholecystokinin mRNA were upregulated in the substantia nigra and ventral tegmental area in the course of the day. However, in the caudate putamen, the mRNA levels, for dopamine D2 and adenosine 2A receptor, dynorphin, and substance P were lower during the day than during the night, whereas the expression of dopamine D1 receptor, enkephalin, and somatostatin was stable. In the frontal cortex, a clear midday peak of enkephalin expression was detected, while cholecystokinin and vasoactive intestinal peptide expression did not vary. Clear circadian gene expression patterns can therefore be demonstrated in brain regions involved in motor regulation, but they do not follow a simple dopaminergic drive and more complex regulatory patterns have to be assumed.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10fdecc9b1ec678973c8488de23457cdTest
https://doi.org/10.1016/j.neulet.2003.12.053Test

المؤلفون: Li-Yen Lee, Akhlaq A. Farooqui, Gavin S. Dawe, Wei-Yi Ong, Jean-Marc Burgunder

المصدر: Neuroscience Letters. 453:6-8

مصطلحات موضوعية: Male, Reflex, Startle, medicine.medical_specialty, Phospholipase A2 Inhibitors, Striatum, Phospholipase A2, Internal medicine, Moro reflex, medicine, Animals, Enzyme Inhibitors, Rats, Wistar, Prepulse inhibition, Analysis of Variance, Phospholipase A, biology, Chemistry, General Neuroscience, Oligonucleotides, Antisense, Startle reaction, Rats, Phospholipases A2, Endocrinology, Acoustic Stimulation, Quinacrine, Acoustic Startle Reflex, Phospholipases A2, Calcium-Independent, Reflex, biology.protein, Neuroscience

الوصف: High levels of calcium-independent phospholipase A(2) (iPLA(2)) are present in the striatum and cerebral cortex [W.Y. Ong, J.F. Yeo, S.F. Ling, A.A. Farooqui, Distribution of calcium-independent phospholipase A(2) (iPLA(2)) in monkey brain, J. Neurocytol. 34 (2005) 447-458], and several clinical investigations have suggested a possible role of altered iPLA(2) activity in neurodegenerative and psychiatric disorders. The present study was carried out to elucidate a possible effect of PLA(2) on prepulse inhibition (PPI) of the acoustic startle reflex. Rats that received intraperitoneal injection of the non-specific PLA(2) inhibitor, quinacrine, showed significantly decreased PPI at 76, 80, and 84dB, compared to saline injected controls. In addition, rats that received intrastriatal injection of antisense oligonucleotide to iPLA(2) showed significant reduction in PPI at prepulse intensities of 76 and 84dB compared to scrambled sense injected controls. Together, these findings point to a role of PLA(2) in PPI of the auditory startle reflex and sensorimotor gating.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd83756bcd4d5c25bafaaa498dab49c8Test
https://doi.org/10.1016/j.neulet.2009.01.069Test

المؤلفون: Cong-Xia Lu, Qi-Lin Ma, Xiao-Rong Zhang, Jean-Marc Burgunder, Qing Lin, Xingkai An, Hongli Qu

المصدر: Neuroscience letters. 549

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, China, Genotype, Aura, Migraine Disorders, Gastroenterology, Polymorphism, Single Nucleotide, Asian People, Gene Frequency, Polymorphism (computer science), Internal medicine, medicine, Humans, Genetic Predisposition to Disease, Allele, Allele frequency, Lymphotoxin-alpha, Monoamine Oxidase, Alleles, Genetic Association Studies, Methylenetetrahydrofolate Reductase (NADPH2), Genetics, biology, business.industry, General Neuroscience, Middle Aged, medicine.disease, Migraine with aura, Migraine, Methylenetetrahydrofolate reductase, Case-Control Studies, biology.protein, Female, medicine.symptom, business

الوصف: A number of genes have been implicated in the pathogenesis of migraine, a common neurological disorder also in China. However, data on association of genetic variations with migraine susceptibility among Chinese, which might be different from people of other ethnic background, are still scarce. We have therefore investigated the association of polymorphisms in four genes, MTHFR C677T, ACE I/D, MAOA T941G and TNF-β G252A, which are considered to be with risk of migraine. A case-control study including a cohort of 151 migraine cases and 137 ethnically matched controls was conducted. The genotypes of each polymorphism followed the Hardy-Weinberg equilibrium in the two groups. Genotypic distribution of MTHFR C677T was significantly different with higher frequency of allele T in the migraine cohort as compared with that in controls (OR=1.686, 95%CI: 1.175-2.420, P=0.004). No difference was found between migraine with aura (MA) patients and controls, but T allele frequency was significantly higher in migraine without aura (MO) than in controls (OR=1.744, 95% CI: 1.202-2.532, P=0.003). No difference in genotypic and allelic distributions was observed between migraine patients and controls for the other polymorphisms, including ACE I/D, MAOA T941G, and TNF-β G252A. Our data suggested that MTHFR C677T polymorphism plays a role in Chinese migraine susceptibility, especially in MO.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760e5c59d44a69308955935743312675Test
https://pubmed.ncbi.nlm.nih.gov/23811028Test

المؤلفون: Alain Kaelin-Lang, Theres Lauterburg, Jean-Marc Burgunder

المصدر: Neuroscience Letters. 261:189-191

مصطلحات موضوعية: Olfactory system, Receptor, Adenosine A2A, Central nervous system, Adenosine A2A receptor, Olfaction, Striatum, Biology, Mice, Species Specificity, medicine, Animals, RNA, Messenger, Rats, Wistar, In Situ Hybridization, General Neuroscience, Receptors, Purinergic P1, Spinal cord, Olfactory Bulb, Rats, Olfactory bulb, Cell biology, medicine.anatomical_structure, Spinal Cord, Female, Olfactory ensheathing glia, Oligonucleotide Probes, Neuroscience

الوصف: The expression of adenosine A2a receptors (A2aR) in the mammalian striatum is well known. In contrast the exact distribution of A2aR in other regions of the central nervous system remains unclear. The aim of this study was to investigate the A2aR gene expression in the rat olfactory bulb and spinal cord, two regions which are seldom included in mapping studies. Secondly, we compared the A2aR expression in the rat and in the mouse brain. Hybridization histochemistry was performed with an S35-labelled radioactive oligonucleotide probe. The results show strong expression of A2aR in the mouse and rat striatum in accordance with previous reports. In the olfactory bulb a weak but specific expression of A2aR was found in the granular cell layer in both species. In contrast, no significant expression of the A2aR gene was observed in other parts of the brain or the rat spinal cord. The presence of the A2aR in the mammalian olfactory bulb suggests a functional role for this receptor in olfaction.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dd981d5e1e91eb08fc4daa1038ae0bdTest
https://doi.org/10.1016/s0304-3940Test(99)00022-1

المؤلفون: Rong Peng, X.-K. An, W.-J. Chen, G.-G. Yuan, Jin-Hong Zhang, X.-Y. Mao, Yingcheng Wang, Zhichao Zhang, Jean-Marc Burgunder, Yuejing Wu, Y.-R. Gou, Yanming Xu

المصدر: Neuroscience letters. 442(3)

مصطلحات موضوعية: Adult, Male, Pathology, medicine.medical_specialty, Parkinson's disease, Population, Disease, Polymorphism, Single Nucleotide, Degenerative disease, Asian People, Polymorphism (computer science), medicine, Humans, Genetic Predisposition to Disease, Allele, education, Aged, Genetics, Aged, 80 and over, education.field_of_study, business.industry, Reverse Transcriptase Polymerase Chain Reaction, General Neuroscience, Parkinson Disease, Middle Aged, medicine.disease, Genotype frequency, Case-Control Studies, Female, Gene polymorphism, business, Ubiquitin Thiolesterase

الوصف: Mutation in UCH-L1 has been reported as a rare cause of autosomal dominant Parkinson's disease (PD). A S18Y polymorphism in the same gene has been associated with sporadic PD. We investigated the frequency of this polymorphism among the Han-Chinese ethnic population in a case–control study. A total of 600 patients with PD and 334 unrelated healthy controls were genotyped using PCR-restriction fragment length polymorphism analysis. We did not observe any difference in allele or genotype frequencies between the cases and the controls ( P > 0.05). Our results do not support a role for this variant in sporadic PD.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a75b03d90490e7a92826c46526ca49fTest
https://pubmed.ncbi.nlm.nih.gov/18638528Test

المؤلفون: Hui-Fang Shang, Jian-Gang Wang, Qin Chen, Qiyong Gong, Dong Zhou, Su Lui, Jean-Marc Burgunder, Luo Ouyang

المصدر: Neuroscience letters. 441(1)

مصطلحات موضوعية: Adult, Male, Pathology, medicine.medical_specialty, Brain Mapping, Internal capsule, Hereditary spastic paraplegia, Spastic Paraplegia, Hereditary, General Neuroscience, Statistical parametric mapping, Corpus callosum, medicine.disease, Corpus Callosum, White matter, medicine.anatomical_structure, Diffusion Magnetic Resonance Imaging, Fractional anisotropy, medicine, Cingulum (brain), Humans, Agenesis of Corpus Callosum, Psychology, Diffusion MRI

الوصف: Hereditary spastic paraplegia (HSP) associated with thin corpus callosum is a rare autosomal recessive neurodegenerative disorder characterized by an abnormally thin corpus callosum, normal motor development, slowly progressive spastic paraparesis and cognitive deterioration. To investigate and localize abnormalities in the brains of two Chinese patients with HSP-TCC, with mutations in the spatacsin gene. Diffusion tensor imaging (DTI) was used to determine the mean diffusion (MD) and fractional anisotropy (FA) in the brains of the patients in comparison to 20 healthy subjects. Voxel-based analysis (VBA) of both the diffusion and anisotropy values were performed using statistical parametric mapping (SPM). Significant changes with MD increase and FA reduction were found in the already known lesions including the corpus callosum, cerebellum and thalamus. In addition, changes were also found in regions that appear to be normal in conventional MRI, such as the brain stem, internal capsule, cingulum and subcortical white matter including superior longitudinal fascicle and inferior longitudinal fascicle. Neither increase in FA nor reduction in MD was detected in the brain. Our study provides clear in vivo MR imaging evidence of a more widespread brain involvement of HSP-TCC. MD is more sensitive than FA in detecting lesions in thalamus and subcortical white matter, suggesting that MD may be a better marker of the disease progression.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfea08e763743be381c53d1201914d2aTest
https://pubmed.ncbi.nlm.nih.gov/18586399Test

المؤلفون: Theres Lauterburg, Jean-Marc Burgunder, Alain Kaelin-Lang

المصدر: Neuroscience letters. 246(1)

مصطلحات موضوعية: Male, Sympathetic nervous system, Superior cervical ganglion, Receptor, Adenosine A2A, General Neuroscience, Central nervous system, Purinergic receptor, Autonomic ganglion, Receptors, Purinergic P1, Adenosine A2A receptor, Biology, Ganglion, Cell biology, Rats, medicine.anatomical_structure, Peripheral nervous system, Ganglia, Spinal, medicine, Animals, Female, Rats, Wistar, Oligonucleotide Probes, Neuroscience, Ganglia, Autonomic, In Situ Hybridization

الوصف: The adenosine A2a receptors (A2aR) play an important role in the purinergic mediated neuromodulation. The presence of A2aR in the brain is well established. In contrast, little is known about their expression in the periphery. The purpose of this study was to investigate the expression of A2aR gene in the autonomic (otic, sphenopalatine, ciliary, cervical superior ganglia and carotid body) and in the dorsal root ganglia of normal rat. Hybridization histochemistry with S35-labelled radioactive oligonucleotide probes was used. An expression of A2aR gene was found in the large neuronal cells of the rat dorsal root ganglia. The satellite cells showed no expression of A2aR gene. In the superior cervical ganglion, isolated ganglion cells expressed A2aR. In the carotid body clusters of cells with a strong A2aR gene expression were found. In contrast, the ciliary and otic ganglia did not expressed A2aR gene, and only few small sized A2aR expressing cells were demonstrated in the sphenopalatine ganglion. The discrete distribution of A2aR gene expression in the peripheral nervous system speaks for a role of this receptor in the purinergic modulation of sensory information as well as in the sympathetic nervous system.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1796fd5f4db908b6f31f8de47174f422Test
https://pubmed.ncbi.nlm.nih.gov/9622198Test

المؤلفون: Shang, Huifang^1,2, Lang, Doris³, Jean-Marc, Burgunder^2,4, Kaelin-Lang, Alain² alain.kaelin@dkf.unibe.ch

المصدر: Neuroscience Letters. Sep2004, Vol. 367 Issue 3, p273-277. 5p.

مصطلحات موضوعية: *MESSENGER RNA, *CENTRAL nervous system, *NEUROSCIENCES, *SYMPTOMS, *MICE

مستخلص: DJ-1 is mutated in autosomal recessive, early onset Parkinson’s disease but the exact localization of the DJ-1 gene product in the mammalian brain is largely unknown. We aimed to evaluate the DJ-1 mRNA expression pattern in the mouse brain. Serial coronal sections of brains of five male and five female adult mice were investigated by using in situ hybridization with a DJ-1 specific 35S-labeled oligonucleotide probe. Hybridized sections were analyzed after exposure to autoradiography films and after coating with a photographic emulsion. DJ-1 was heterogeneously expressed throughout the mouse central nervous system. A high expression of DJ-1 mRNA was detected in neuronal and non-neuronal populations of several structures of the motor system such as the substantia nigra, the red nucleus, the caudate putamen, the globus pallidus, and the deep nuclei of the cerebellum. Furthermore, DJ-1 mRNA was also highly expressed in non-motor structures including the hippocampus, the olfactory bulb, the reticular nucleus of the thalamus, and the piriform cortex. The high expression of DJ-1 mRNA in brain regions involved in motor control is compatible with the occurrence of parkinsonian symptoms after DJ-1 mutations. However, expression in other regions indicates that a dysfunction of DJ-1 may contribute to additional clinical features in patients with a DJ-1 mutation. [Copyright &y& Elsevier]