التفاصيل البيبلوغرافية
| العنوان: |
Chrysotoxine, a novel bibenzyl compound selectively antagonizes MPP+, but not rotenone, neurotoxicity in dopaminergic SH-SY5Y cells |
| المؤلفون: |
Song, Ju-Xian1, Shaw, Pang-Chui2, Wong, Ngok-Shun3, Sze, Cho-Wing1, Yao, Xin-Sheng4, Tang, Chi-Wai5, Tong, Yao1 tongyao@hku.hk, Zhang, Yan-Bo1 zhang.yanbo@yahoo.com |
| المصدر: |
Neuroscience Letters. Jul2012, Vol. 521 Issue 1, p76-81. 6p. |
| مصطلحات موضوعية: |
*BIBENZYLS, *ROTENONE, *NEUROTOXICOLOGY, *DOPAMINERGIC neurons, *DENDROBIUM, *MEDICINAL plants, *HORSERADISH peroxidase, *LACTATE dehydrogenase, *MITOGEN-activated protein kinases |
| مستخلص: |
Abstract: Chrysotoxine is a naturally occurring bibenzyl compound found in medicinal Dendrobium species. We previously reported that chrysotoxine structure-specifically suppressed 6-hydroxydopamine (6-OHDA)-induced dopaminergic cell death. Whether chrysotoxine and other structurally similar bibenzyl compounds could also inhibit the neurotoxicity of 1-methyl-4-phenyl pyridinium (MPP+) and rotenone has not been investigated. We showed herein that chrysotoxine inhibited MPP+, but not rotenone, induced dopaminergic cell death in SH-SY5Y cells. The overproduction of reactive oxygen species (ROS), mitochondrial dysfunction as indexed by the decrease in membrane potential, increase in calcium concentration and NF-κB activation triggered by MPP+ were blocked by chrysotoxine pretreatment. The imbalance between the pro-apoptotic signals (Bax, caspase-3, ERK and p38 MAPK) and the pro-survival signals (Akt/PI3K/GSK-3β) induced by MPP+ was partially or totally rectified by chrysotoxine. The results indicated that ROS inhibition, mitochondria protection, NF-κB modulation and regulation of multiple signals determining cell survival and cell death were involved in the protective effects of chrysotoxine against MPP+ toxicity in SH-SY5Y cells. Given the different toxic profiles of 6-OHDA and MPP+ as compared to rotenone, our results also indicated that DAT inhibition may partially account for the neuroprotective effects of chrysotoxine. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
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