دورية أكاديمية
Effects of the Dual Orexin Receptor Antagonist DORA-22 on Sleep in 5XFAD Mice
| العنوان: | Effects of the Dual Orexin Receptor Antagonist DORA-22 on Sleep in 5XFAD Mice |
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| المؤلفون: | Duncan, Marilyn J., Farlow, Hannah, Tirumalaraju, Chairtra, Yun, Do-Hyun, Wang, Chanung, Howard, James A., Sanden, Madison N., O'Hara, Bruce F., McQuerry, Kristen J., Bachstetter, Adam D. |
| المصدر: | Neuroscience Faculty Publications |
| بيانات النشر: | UKnowledge |
| سنة النشر: | 2019 |
| المجموعة: | University of Kentucky: UKnowledge |
| مصطلحات موضوعية: | Sleep-wake cycles, Sleep fragmentation, Orexin, Dual orexin receptor antagonist, Amyloid β, Neuroinflammation, Alzheimer's disease, Diseases, Neuroscience and Neurobiology, Translational Medical Research |
| الوصف: | Introduction: Sleep disruption is a characteristic of Alzheimer's disease (AD) that may exacerbate disease progression. This study tested whether a dual orexin receptor antagonist (DORA) would enhance sleep and attenuate neuropathology, neuroinflammation, and cognitive deficits in an AD-relevant mouse model, 5XFAD. Methods: Wild-type (C57Bl6/SJL) and 5XFAD mice received chronic treatment with vehicle or DORA-22. Piezoelectric recordings monitored sleep and spatial memory was assessed via spontaneous Y-maze alternations. Aβ plaques, Aβ levels, and neuroinflammatory markers were measured by immunohistochemistry, enzyme-linked immunosorbent assay, and real-time polymerase chain reaction, respectively. Results: In 5XFAD mice, DORA-22 significantly increased light-phase sleep without reducing Aβ levels, plaque density, or neuroinflammation. Effects of DORA-22 on cognitive deficits could not be determined because the 5XFAD mice did not exhibit deficits. Discussion: These findings suggest that DORAs may improve sleep in AD patients. Further investigations should optimize the dose and duration of DORA-22 treatment and explore additional AD-relevant animal models and cognitive tests. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | Supplementary data related to this article can be found at https://doi.org/10.1016/j.trci.2019.01.003Test .; https://uknowledge.uky.edu/neurobio_facpub/64Test; https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1063&context=neurobio_facpubTest |
| الإتاحة: | https://doi.org/10.1016/j.trci.2019.01.003Test https://uknowledge.uky.edu/neurobio_facpub/64Test https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1063&context=neurobio_facpubTest |
| رقم الانضمام: | edsbas.E85909BE |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |