Cortical and subcortical distribution of ionotropic purinergic receptor subunit type 1 (P2X(1)R) immunoreactive neurons in the rat forebrain
| العنوان: | Cortical and subcortical distribution of ionotropic purinergic receptor subunit type 1 (P2X(1)R) immunoreactive neurons in the rat forebrain |
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| المؤلفون: | Simona Cabib, Claudia Bagni, Maria Teresa Viscomi, Laura Latini, Pascal Carrive, Fulvio Florenzano, David Conversi, Marco Molinari, Francesca Ferrari |
| المصدر: | Neuroscience 151/3 (2008): 791–801. info:cnr-pdr/source/autori:Florenzano F.1,2; Carrive P.3; Viscomi M.T.2; Ferraria F. 2,4; Latini L.2.; Conversi D.2,5; Cabiba S.1, 5, 6; Bagnia C.2,4; Molinari M. 5/titolo:Cortical and subcortical distribution of ionotropic purinergic receptor subunit type 1 (P2X1R) immunoreactive neurons in the rat forebrain/doi:/rivista:Neuroscience/anno:2008/pagina_da:791/pagina_a:801/intervallo_pagine:791–801/volume:151%2F3 |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | cognition, Male, Messenger, Wistar, bed nucleus of stria terminalis, stria terminalis, Hippocampal formation, cingulate cortex, diencephalon, localization, Western blotting, late cortex, Receptors, Basal ganglia, rat, synaptic currents, hypothalamus, p2x receptors, Neurons, prefrontal cortex, cingulate gyrus, General Neuroscience, Settore BIO/13, Purinergic receptor, article, transmission, habenular complex, medicine.anatomical_structure, priority journal, Receptors, Purinergic P2X, immunohistochemistry, brain nerve cell, Settore BIO/17 - ISTOLOGIA, amygdaloid nucleus, immunoreactivity, nucleus centralis of the amygdala, antibody labeling, brain-stem, Ionotropic effect, somatosensory cortex, forebrain, adenosine receptor, ionotropic receptor, animal tissue, brain cortex, controlled study, dendrite, fluorescence in situ hybridization, habenula, immunocompetent cell, male, nerve fiber, nonhuman, protein expression, protein localization, Animals, Glial Fibrillary Acidic Protein, Phosphopyruvate Hydratase, Prosencephalon, Rats, Rats, Wistar, Receptors, Purinergic P2, RNA, Messenger, Biology, medicine, Purinergic P2, limbic cortex, Stria terminalis, nervous system, molecular physiology, Forebrain, RNA, central-nervous-system, Neuron, Nucleus, Neuroscience |
| الوصف: | Ionotropic purinergic receptors (P2XR) are ATP-gated cationic channels composed of seven known subunits (P2X(1-7)R) and involved in different functions in neural tissue. Although their presence has been demonstrated in the brain, few studies have investigated their expression pattern. In particular, ionotropic purinergic receptor subunit type 1 (P2X(1)R) has been observed in the cerebellum and in brain-stem nuclei. The present study investigates the P2X(1)R expression pattern in the rat forebrain using immunohistochemistry. The specificity of the immunolabeling has been verified by Western blotting and in situ hybridization methods. P2X(1)R immunoreactivity was specifically localized in neurons, dendrites and axons throughout the forebrain. Characteristic differences in the distribution of P2X(1)R were observed in different cortical areas. In prefrontal, cingulate and perirhinal cortices, very intense labeling was present in neuronal bodies. In frontal, parietal, temporal and occipital cortices, immunostaining was lighter and mainly found in dendrites and axons. The hippocampal formation was intensely labeled. Labeling was present almost exclusively in dendrites and axons and never in neuronal bodies. The diencephalon was devoid of P2X(1)R positive neurons or fibers except for the medial habenular nucleus, which showed very intense P2X(1)R immunostaining. Furthermore two subcortical regions, namely, the nucleus centralis of the amygdala and the bed nucleus of the stria terminalis, showed intense P2X(1)R neuronal labeling. Present data indicate that P2X(1)R are prevalent in forebrain areas involved in the integration of cognitive, limbic and autonomic functions. (c) 2007 IBRO. Published by Elsevier Ltd. All rights reserved. ispartof: Neuroscience vol:151 issue:3 pages:791-801 ispartof: location:United States status: published |
| وصف الملف: | Print-Electronic; application/pdf |
| تدمد: | 0306-4522 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c59ead923795df01176e8dfe6910463dTest https://pubmed.ncbi.nlm.nih.gov/18178317Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c59ead923795df01176e8dfe6910463d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 03064522 |
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