Safety of oral anticoagulants on experimental brain microbleeding and cognition
| العنوان: | Safety of oral anticoagulants on experimental brain microbleeding and cognition |
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| المؤلفون: | Petrault, Maud, Ouk, Thavarak, Petrault, Olivier, Bastide, Michele, Bordet, Regis, Berezowski, Vincent |
| المساهمون: | CHU Lille, CNRS, Inserm, Université de Lille, Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV], Troubles cognitifs dégénératifs et vasculaires - U1171, Troubles cognitifs dégénératifs et vasculaires - U 1171 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille) |
| المصدر: | Neuropharmacology Neuropharmacology, Elsevier, 2019, Neuropharmacology, 155, pp.162-172. ⟨10.1016/j.neuropharm.2019.05.030⟩ Neuropharmacology, 2019, Neuropharmacology, 155, pp.162-172. ⟨10.1016/j.neuropharm.2019.05.030⟩ |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, [SDV]Life Sciences [q-bio], Preclinical model, Oral anticoagulation, Administration, Oral, Anticoagulants, respiratory system, Rodents, Mice, Inbred C57BL, Mice, Cognitive impairment, Cognition, Memory, Microvessels, Cerebral microbleeds, Animals, Cerebral Hemorrhage |
| الوصف: | International audience; This study aims at determining the ability of clinical-based doses of four oral anticoagulants to transform the onset of a cerebral microhemorrhages (CMH) burden into a symptomatic intracerebral hemorrhage (ICH) in the healthy brain, and precipitate cognitive impairment. Wild-type mice were anticoagulated for 10 days using apixaban, rivaroxaban or dabigatran as direct oral anticoagulants (DOACs), or warfarin as vitamin K-antagonist. Meanwhile, a burden of ∼20 CMHs was induced in the Sylvian territory by intra-carotid injection of cyclodextrin nanoparticles. At bleeding onset, only warfarin provoked deadly hematoma, and dramatically increased mortality (+45%). All the DOACs enhanced CMH burden through a greater number of intermediate-sized microhemorrhages (+80% to +180%). Although silent at onset, both baseline- and anticoagulant-enhanced CMH burdens increased mortality (+11% to +58%) along the following year without statistical difference among groups, and despite cessation of anticoagulation and absence of CMH progression or transformation into ICH. All survivor mice exhibited reduction in visual recognition memory from 9 months. In the healthy brain, DOACs preserve the onset of microhemorrhages from transformation into ICH, and do not precipitate cognitive impairment despite enhancement of CMH burden. High CMH burdens should however be considered for early detection and preventive memory care apart from anticoagulation decisions. |
| وصف الملف: | application/octet-stream; application/rdf+xml; charset=utf-8 |
| تدمد: | 1873-7064 0028-3908 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c862770f3ea5716d46a1f9ebf1c5fb27Test https://pubmed.ncbi.nlm.nih.gov/31132437Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....c862770f3ea5716d46a1f9ebf1c5fb27 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18737064 00283908 |
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