التفاصيل البيبلوغرافية
| العنوان: |
The specific VPAC2 agonist Bay 55-9837 increases neuronal damage and hemorrhagic transformation after stroke in type 2 diabetic rats. |
| المؤلفون: |
Darsalia, Vladimer, Mansouri, Shiva, Wolbert, Petra, Barde, Swapnali, Sjöholm, Åke, Patrone, Cesare |
| المصدر: |
Neuropeptides; Apr2013, Vol. 47 Issue 2, p133-137, 5p |
| مصطلحات موضوعية: |
NEURONS, BRAIN damage, STROKE, LABORATORY rats, TYPE 2 diabetes treatment, PHARMACODYNAMICS, DEATH rate, HYPOGLYCEMIC agents |
| مستخلص: |
Abstract: VPAC2 receptor is a potential target for the treatment of type 2 diabetes and may also convey neuroprotective effects. The aim of this study was to determine the potential efficacy of the VPAC2 receptor agonist Bay 55-9837 against stroke in type-2 diabetic Goto-Kakizaki (GK) rats. GK rats were treated intravenously once daily for 7days with 0.25 or 0.025nmol/kg Bay 55–9837 or vehicle before inducing stroke by transient middle cerebral artery occlusion. Treatments were then continued for 7 further days. The glycemic effects of Bay 55-9837 were assessed by measuring fasting blood glucose and oral glucose tolerance. The severity of stroke was measured by assessing ischemic volume. The results show that Bay 55-9837 is not effective in lowering fasting glycemia and does not facilitate glucose disposal. The highest dose of Bay 55-9837 (0.25nmol/kg) led to increased mortality and brain hemorrhage when compared to control. The lower dose of Bay 55-9837 (0.025nmol/kg) did not increase mortality rate but caused a threefold increase of the ischemic lesion size with signs of brain hemorrhages as compared to control. In conclusion, Bay 55-9837 did not show antidiabetic or antistroke efficacy in the type 2 diabetic GK rat. Contrarily, Bay 55-9837 treatment led to increased mortality and worsening of the severity of stroke. [Copyright &y& Elsevier] |
|
Copyright of Neuropeptides is the property of Churchill Livingstone, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Supplemental Index |
