Testosterone Treatment of Pubertal Delay in Duchenne Muscular Dystrophy
| العنوان: | Testosterone Treatment of Pubertal Delay in Duchenne Muscular Dystrophy |
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| المؤلفون: | Kate Bushby, Volker Straub, Helen Johnstone, Michela Guglieri, Catherine Owen, Claire L Wood, Tim Cheetham |
| المصدر: | Neuropediatrics. 46:371-376 |
| بيانات النشر: | Georg Thieme Verlag KG, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Adolescent, Duchenne muscular dystrophy, Physiology, Controlled studies, Pubertal Delay, Testosterone treatment, Internal medicine, medicine, Humans, Testosterone, Muscular dystrophy, Glucocorticoids, Retrospective Studies, Puberty, Delayed, business.industry, Retrospective cohort study, Testosterone (patch), General Medicine, Exogenous testosterone, medicine.disease, Body Height, Muscular Dystrophy, Duchenne, Endocrinology, Pediatrics, Perinatology and Child Health, Neurology (clinical), business |
| الوصف: | The outlook for adolescents with Duchenne muscular dystrophy (DMD) has improved greatly as a result of corticosteroid use, but treatment will compromise growth and delay puberty. Whether exogenous testosterone can promote growth, development, and skeletal health is unclear.We collected data retrospectively on growth and pubertal response in 14 adolescents with DMD who were treated with testosterone between 2008 and 2014.A total of 14 boys were treated at a median age of 14.5 years. Eight have finished treatment after a mean age of 3.1 years and the feedback from families was generally positive. The mean testicular volume pretreatment was 2.4 and 3.9 mL posttreatment. The mean baseline testosterone concentrations were 1.0 and 5.4 nmol/L postintervention. Median height velocity increased from 0.45 cm/y before treatment to 3.6 cm/y after the treatment. The mean height gain was 14.2 cm.A broad range of testosterone preparations was used. Testosterone was generally well-liked, but side effects were experienced by some patients and the pubertal growth increment appears to be compromised. Few subjects had adult endogenous testosterone levels posttreatment. Controlled studies are required to determine the most appropriate treatment regimen and the precise impact of testosterone on key outcomes, such as muscle function and bone integrity. Clinicians will then be better placed to advise families about likely benefits and risks. |
| تدمد: | 1439-1899 0174-304X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9c2e33b030e1a2b79cabaf684bfdd1Test https://doi.org/10.1055/s-0035-1563696Test |
| رقم الانضمام: | edsair.doi.dedup.....cd9c2e33b030e1a2b79cabaf684bfdd1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14391899 0174304X |
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