High‐grade gliomas with isocitrate dehydrogenase wild‐type and 1p/19q codeleted: Atypical molecular phenotype and current challenges in molecular diagnosis
| العنوان: | High‐grade gliomas with isocitrate dehydrogenase wild‐type and 1p/19q codeleted: Atypical molecular phenotype and current challenges in molecular diagnosis |
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| المؤلفون: | Qiao Zhou, Ling Nie, Jing Gong, Ni Chen, Linmao Zheng, Mengni Zhang, Xueqin Chen, Jing Hou |
| المصدر: | Neuropathology. 40:599-605 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, Mutant, 1p/19q Codeletion, Biology, medicine.disease_cause, Pathology and Forensic Medicine, 03 medical and health sciences, Diffuse Glioma, 0302 clinical medicine, Glioma, medicine, Humans, neoplasms, Chromosome Aberrations, Mutation, Brain Neoplasms, Wild type, General Medicine, Middle Aged, medicine.disease, Isocitrate Dehydrogenase, nervous system diseases, Isocitrate dehydrogenase, Chromosomes, Human, Pair 1, 030220 oncology & carcinogenesis, Cancer research, Immunohistochemistry, Female, Neurology (clinical), 030217 neurology & neurosurgery |
| الوصف: | Glioma is the most common intracranial malignant tumor, with poor prognosis. The new World Health Organization (WHO) integrated classification (2016) for diffuse glioma is mainly based on the status of the isocitrate dehydrogenase (IDH) gene (IDH) mutation and 1p/19q codeletion, with diffuse glioma separated into three distinct molecular categories: chromosome 1p/19q codeletion/IDH mutant, 1p/19q intact /IDH mutant, and IDH wild-type. Gliomas harboring 1p/19q codeletion but without IDH mutation are rare and cannot be classified according to the new revision of the WHO classification. Here we report three high-grade gliomas with this atypical molecular phenotype, and describe their histological and immunohistochemical features, the status of mutations in TERT promopter, H3F3A, HIST1H3B, and BRAF, as well as MGMT promoter methylation, and prognosis. Considering morphology, molecular parameters, and patients prognosis, we found that high-grade gliomas harboring 1p/19q codeletion but without IDH mutation were not typical glioblastoma multiforme (GBM) but were more likely to be GBM than anaplastic oligodendroglioma. |
| تدمد: | 1440-1789 0919-6544 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eb5a18db6f89f5d2da9f8f3edd4fa8dTest https://doi.org/10.1111/neup.12672Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....6eb5a18db6f89f5d2da9f8f3edd4fa8d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14401789 09196544 |
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