التفاصيل البيبلوغرافية
| العنوان: |
Endothelium-Derived Semaphorin 3G Regulates Hippocampal Synaptic Structure and Plasticity via Neuropilin-2/PlexinA4. |
| المؤلفون: |
Tan, Chao1 (AUTHOR), Lu, Nan-Nan1 (AUTHOR), Wang, Cheng-Kun1 (AUTHOR), Chen, Dan-Yang1 (AUTHOR), Sun, Ning-He1 (AUTHOR), Lyu, Hang1 (AUTHOR), Körbelin, Jakob2,3 (AUTHOR), Shi, Wei-Xing4 (AUTHOR), Fukunaga, Kohji5 (AUTHOR), Lu, Ying-Mei1,6,7 (AUTHOR) lufx@njmu.edu.cn, Han, Feng1,8 (AUTHOR) fenghan169@njmu.edu.cn |
| المصدر: |
Neuron. Mar2019, Vol. 101 Issue 5, p920-920. 1p. |
| مصطلحات موضوعية: |
*VASCULAR endothelial cells, *NEUROPLASTICITY, *CENTRAL nervous system, *NEURAL circuitry, *SEMAPHORINS, *LONG-term synaptic depression |
| مستخلص: |
Summary The proper interactions between blood vessels and neurons are critical for maintaining the strength of neural circuits and cognitive function. However, the precise molecular events underlying these interactions remain largely unknown. Here, we report that the selective knockout of semaphorin 3G (Sema3G) in endothelial cells impaired hippocampal-dependent memory and reduced dendritic spine density in CA1 neurons in mice; these effects were reversed after restoration of Sema3G levels in the hippocampus by AAV transfection. We further show that Sema3G increased excitatory synapse density via neuropilin-2/PlexinA4 signaling and through activation of Rac1. These results provide the first evidence that, in the central nervous system, endothelial Sema3G serves as a vascular-derived synaptic organizer that regulates synaptic plasticity and hippocampal-dependent memory. Our findings highlight the role of vascular endothelial cells in regulating cognitive function through intercellular communication with neurons in the hippocampus. Graphical Abstract Highlights • Endothelium-derived Sema3G is necessary for synaptic plasticity in the hippocampus • Loss of Sema3G in the vascular endothelium results in behavioral and memory deficits • Sema3G regulates synaptic structure and function via the neuropilin-2/PlexinA4 receptor • Sema3G functionally links the endothelium to signaling cascades activated in neurons Tan et al. reveal a key mechanism that underlies signaling from endothelial cells to neurons in the brain. They identify that the endothelium-secreted protein semaphorin 3G (Sema3G) regulates synaptic structure and plasticity in hippocampal neurons through its neuronal neuropilin-2/PlexinA4 holoreceptor. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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