دورية
Familial Alzheimer disease Decreases in CSF A42levels precede cognitive decline
| العنوان: | Familial Alzheimer disease Decreases in CSF A42levels precede cognitive decline |
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| المؤلفون: | Moonis, M, Swearer, J M., Dayaw, M P. E., St. George-Hyslop, P, Rogaeva, E, Kawarai, T, Pollen, D A. |
| المصدر: | Neurology (Ovid); July 2005, Vol. 65 Issue: 2 p323-325, 3p |
| مستخلص: | CSF amyloid -peptide 42 (A42) levels in presymptomatic subjects with pathogenic mutations in the PS1gene are significantly lower than in an age-matched control group. Consequently, in these subjects, there is a window of opportunity estimated as at least 4 to 12 years to evaluate the ability of any putative prophylactic therapy to decrease, arrest, or reverse abnormalities in A42metabolism many years before clinical symptoms of Alzheimer disease are otherwise likely to occur. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 00283878 1526632X |
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| DOI: | 10.1212/01.wnl.0000171397.32851.bc |