دورية
Neuropathology of primary adult-onset dystonia
| العنوان: | Neuropathology of primary adult-onset dystonia |
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| المؤلفون: | Holton, J L., Schneider, S A., Ganesharajah, T, Gandhi, S, Strand, C, Shashidharan, P, Barreto, J, Wood, N W., Lees, A J., Bhatia, K P., Revesz, T |
| المصدر: | Neurology (Ovid); February 2008, Vol. 70 Issue: 9 p695-699, 5p |
| مستخلص: | Idiopathic adult-onset primary dystonia usually affects the upper body and remains focal. Underlying mechanisms are unknown, and there are only limited neuropathologic studies in the literature. Recently, ubiquitinated perinuclear inclusion bodies were found in the brainstem of patients with DYT1-related dystonia. In X-linked recessive dystonia-parkinsonism, neuronal loss in the striosome compartment of the striatum has been described. However, it was unclear whether these changes are characteristic of these particular disorders or an epiphenomenon of dystonic conditions in general. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 00283878 1526632X |
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| DOI: | 10.1212/01.wnl.0000302175.76229.f0 |