دورية
Cerebral edema secondary to chimeric antigen receptor T-cell immunotherapy
| العنوان: | Cerebral edema secondary to chimeric antigen receptor T-cell immunotherapy |
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| المؤلفون: | Guha-Thakurta, Nandita, Wierda, William G. |
| المصدر: | Neurology (Ovid); October 2018, Vol. 91 Issue: 18 p843-843, 1p |
| مستخلص: | A 40-year-old man with relapsed acute lymphoblastic leukemia received lymphodepleting chemotherapy followed by immunotherapy with autologous T cells expressing a chimeric antigen receptor (CAR) targeting CD19. Two days after infusion of CD19-CAR-T cells, he developed fever refractory to acetaminophen; received a dose of the interleukin-6 receptor inhibitor, tocilizumab; and defervesced. Five days later, he had recurrent fever and rapid onset of mental status changes. Over the subsequent hours, he developed seizures and became obtunded. MRI revealed cerebral edema (figure, B) associated with his progressive and fulminant CAR-T-cell–related encephalopathy syndrome, which was irreversible, and resulted in brain death.1,2 |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 00283878 1526632X |
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| DOI: | 10.1212/WNL.0000000000006436 |