Pretreatment ASPECTS on DWI predicts 3-month outcome following rt-PA: SAMURAI rt-PA Registry
| العنوان: | Pretreatment ASPECTS on DWI predicts 3-month outcome following rt-PA: SAMURAI rt-PA Registry |
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| المؤلفون: | Masaki Naganuma, Kazuomi Kario, Satoshi Okuda, Yoshiaki Shiokawa, Yasushi Okada, Kazutoshi Nishiyama, K. Minematsu, Eisuke Furui, Kazunori Toyoda, Jyoji Nakagawara, Masatoshi Koga, Tomohisa Nezu, Kazumi Kimura, Yasuhiro Hasegawa, Hiroshi Yamagami |
| المصدر: | Neurology. 75:555-561 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Stroke patient, Severity of Illness Index, Primary outcome, Fibrinolytic Agents, Japan, Predictive Value of Tests, Modified Rankin Scale, Interquartile range, Internal medicine, medicine, Humans, Registries, cardiovascular diseases, Stroke, Aged, Retrospective Studies, Aged, 80 and over, Intracerebral hemorrhage, NIH stroke scale, business.industry, Middle Aged, medicine.disease, Recombinant Proteins, Surgery, Treatment Outcome, Tissue Plasminogen Activator, Female, Neurology (clinical), business |
| الوصف: | To evaluate whether the pretreatment Alberta Stroke Programme Early CT Score (ASPECTS) assessed using diffusion-weighted imaging (DWI) predicts stroke outcomes at 3 months following IV recombinant tissue-type plasminogen activator (rt-PA) therapy.Stroke patients treated with rt-PA (0.6 mg/kg alteplase) in 10 stroke centers in Japan were retrospectively studied. ASPECTS was assessed on DWI just prior to rt-PA injection. The primary outcome was a modified Rankin Scale (mRS) score of 0-2 at 3 months. Secondary outcomes included death at 3 months and symptomatic intracerebral hemorrhage (sICH) within 36 hours.For the 477 patients (316 men, 71 +/- 11 years old) enrolled, the median NIH Stroke Scale score was 13 (interquartile range 7-18.5), the median ASPECTS on DWI was 8 (7-10), and sICH was identified in 15 patients (3.1%). At 3 months, 245 (51.4%) had an mRS score of 0-2, and 29 (6.1%) had died. Patients with an mRS score of 0-2 had higher median ASPECTS (9; interquartile range 8-10) than other patients (8; 6-9, p0.001). Using receiver operating characteristic curves, the optimal cutoff ASPECTS to predict an mRS score of 0-2 wasor =7. On multivariate regression analysis, ASPECTSor =7 was related to an mRS score of 0-2 (odds ratio 1.85; 95% confidence interval 1.07-3.24), ASPECTSor =4 was related to death (3.61; 1.23-9.91), and ASPECTSor =5 was related to sICH (4.74; 1.54-13.64).ASPECTS on DWI was independently predictive of functional and vital outcomes at 3 months, as well as sICH within 36 hours, following rt-PA therapy for stroke patients. |
| تدمد: | 1526-632X 0028-3878 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::902319dd54ab01a79d9bee1032439167Test https://doi.org/10.1212/wnl.0b013e3181eccf78Test |
| رقم الانضمام: | edsair.doi.dedup.....902319dd54ab01a79d9bee1032439167 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1526632X 00283878 |
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