Changing outcome in inflammatory neuropathies Rasch-comparative responsiveness
العنوان: | Changing outcome in inflammatory neuropathies Rasch-comparative responsiveness |
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المؤلفون: | Hans D. Katzberg, Jean Marc Léger, Kenneth C. Gorson, Eduardo Nobile-Orazio, Catharina G. Faber, Pieter A. van Doorn, Jean Pouget, Giuseppe Lauria, Ingemar S. J. Merkies, Sonja I. van Nes, Angelika F. Hahn, Anneke J. van der Kooi, W. Ludo van der Pol, Leonard H. van den Berg, Nicolette C. Notermans, Peter Van den Bergh, David R. Cornblath, Vera Bril, Els K. Vanhoutte, Thomas H P Draak, Michael P. Lunn |
المساهمون: | Neurology, MUMC+: DA KG Polikliniek (9), RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Klinische Neurowetenschappen, ANS - Amsterdam Neuroscience |
المصدر: | Neurology, 83(23), 2124-2132. Lippincott Williams & Wilkins Neurology, 83(23), 2124-2132. LIPPINCOTT WILLIAMS & WILKINS Neurology, 83(23), 2124-2132. Lippincott Williams and Wilkins |
سنة النشر: | 2014 |
مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Time Factors, Guillain-Barre Syndrome, Severity of Illness Index, New diagnosis, Polyneuropathies, Internal medicine, Gammopathy, medicine, Humans, Aged, Aged, 80 and over, Rasch model, business.industry, Minimal clinically important difference, Polyradiculoneuropathy, Middle Aged, medicine.disease, Standard error, Immunoglobulin M, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating, Physical therapy, Female, Neurology (clinical), sense organs, business, Inflammatory neuropathy, Polyneuropathy |
الوصف: | Objectives: We performed responsiveness comparison between the patient-reported Inflammatory Rasch-built Overall Disability Scale (I-RODS) and the widely used clinician-reported Inflammatory Neuropathy Cause and Treatment-Overall Neuropathy Limitation Scale (INCAT-ONLS) in patients with Guillain-Barre syndrome (GBS), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), and immunoglobulin M-monoclonal gammopathy of undetermined significance related polyneuropathy (IgM-MGUSP). Methods: One hundred thirty-seven patients (GBS: 55, CIDP: 59, IgM-MGUSP: 23) with a new diagnosis or clinical relapse assessed both scales. Patients with GBS/CIDP were examined at 0, 1, 3, 6, and 12 months; patients with IgM-MGUSP at 0, 3, and 12. We subjected all data to Rasch analyses, and calculated for each patient the magnitude of change on both scales using the minimal clinically important difference (MCID) related to the individual standard errors (SEs). A responder was defined as having anMCID-SE >= 1.96. Individual scores on both measures were correlated with the EuroQoL thermometer (heuristic responsiveness). Results: The I-RODS showed a significantly higher proportion of meaningful improvement compared with the INCAT-ONLS findings in GBS/CIDP. For IgM-MGUSP, the lack of responsiveness during the 1-year study did not allow a clear separation. Heuristic responsiveness was consistently higher with the I-RODS. Conclusion: The I-RODS more often captures clinically meaningful changes over time, with a greater magnitude of change, compared with the INCAT-ONLS disability scale in patients with GBS and CIDP. The I-RODS offers promise for being a more sensitive measure and its use is therefore suggested in future trials involving patients with GBS and CIDP. |
اللغة: | English |
تدمد: | 0028-3878 |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b408ec3f92c81a65378b6cc3c9fbbc0fTest https://doi.org/10.1212/wnl.0000000000001044Test |
حقوق: | RESTRICTED |
رقم الانضمام: | edsair.doi.dedup.....b408ec3f92c81a65378b6cc3c9fbbc0f |
قاعدة البيانات: | OpenAIRE |
تدمد: | 00283878 |
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