Clinical, cerebrospinal fluid, and neuroimaging findings in COVID-19 encephalopathy: a case series
| العنوان: | Clinical, cerebrospinal fluid, and neuroimaging findings in COVID-19 encephalopathy: a case series |
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| المؤلفون: | Iago N. Perissinotti, Jerusa Smid, Carlos Benatti Neto, Ida Fortini, Mariana Hiromi Manoel Oku, Bruno Fukelmann Guedes, Adalberto Studart-Neto, Ricardo Nitrini, Gabriel Taricani Kubota, Matheus Dalben Fiorentino, Tarso Adoni, Cesar Castello Branco Lopes, Luiz Henrique Martins Castro, Tomás Silva, Sara Terrim, Antonio Edvan Camelo-Filho, Maíra Medeiros Honorato Ferrari, Rafael Bernhart Carra, Julia Carvalhinho Carlos De Souza, José Pedro Soares Baima, Raphael de Luca e Tuma, Júlia Chartouni Rodrigues, Hélio Rodrigues Gomes, Bruno Diógenes Iepsen, Leandro Tavares Lucato, María M. Martín, Márcia Rúbia Rodrigues Gonçalves |
| المصدر: | Neurological Sciences |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Neurology, Coronavirus disease 2019 (COVID-19), medicine.medical_treatment, CNS demyelination, Encephalopathy, Clinical Neurology, Dermatology, Severity of Illness Index, Gastroenterology, Tertiary Care Centers, 03 medical and health sciences, 0302 clinical medicine, Cerebrospinal fluid, Neuroimaging, Internal medicine, Severity of illness, medicine, Humans, In patient, 030212 general & internal medicine, Hospital Mortality, Dialysis, Neuroradiology, Aged, Retrospective Studies, Aged, 80 and over, Mechanical ventilation, Brain Diseases, business.industry, COVID-19, Retrospective cohort study, General Medicine, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Critical care, Psychiatry and Mental health, Female, Neurology (clinical), Neurosurgery, business, 030217 neurology & neurosurgery |
| الوصف: | ObjectiveTo describe the clinical, neurological, neuroimaging and cerebrospinal fluid (CSF) findings associated with encephalopathy in patients admitted to a COVID-19 tertiary reference center.MethodsWe retrospectively reviewed records of consecutive patients with COVID-19 evaluated by a consulting neurology team from March 30, 2020 through May 15, 2020.ResultsFifty-five patients with confirmed SARS-CoV-2 were included, 43 of whom showed encephalopathy, and were further divided into mild, moderate and severe encephalopathy groups. Nineteen patients (44%) had undergone mechanical ventilation and received intravenous sedatives. Eleven (26%) patients were on dialysis. Laboratory markers of COVID-19 severity were very common in encephalopathy patients, but did not correlate with the severity of encephalopathy. Thirty-nine patients underwent neuroimaging studies, which showed mostly non-specific changes. One patient showed lesions possibly related to CNS demyelination. Four had suffered an acute stroke. SARS-CoV-2 was detected by RT-PCR in only one of 21 CSF samples. Two CSF samples showed elevated white blood cell count and all were negative for oligoclonal bands. In our case series the severity of encephalopathy correlated with higher probability of death during hospitalization (OR = 5.5 for each increment in the degree of encephalopathy, from absent (0) to mild (1), moderate (2) or severe (3), pConclusionIn our consecutive series with 43 encephalopathy cases, neuroimaging and CSF analysis did not support the role of direct viral CNS invasion or CNS inflammation as the cause of encephalopathy. |
| اللغة: | English |
| تدمد: | 1590-3478 1590-1874 |
| DOI: | 10.1007/s10072-020-04946-w |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b0dedb59ed89775d0e42f99f7267539Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7b0dedb59ed89775d0e42f99f7267539 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15903478 15901874 |
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| DOI: | 10.1007/s10072-020-04946-w |