التفاصيل البيبلوغرافية
| العنوان: |
Incidence of SARS-CoV-2 infection in patients with multiple sclerosis who received SARS-CoV-2 vaccines and are under treatment with high-efficacy therapies in Argentina. |
| المؤلفون: |
Carnero Contentti, Edgar1 (AUTHOR) ecarnerocontentti@hospitalaleman.com, López, Pablo A.1 (AUTHOR), Pappolla, Agustín2 (AUTHOR), Alonso, Ricardo3,4 (AUTHOR), Silva, Berenice2,3 (AUTHOR), Deri, Norma5,6 (AUTHOR), Balbuena, María E.7 (AUTHOR), Burgos, Marcos8 (AUTHOR), Luetic, Geraldine9 (AUTHOR), Alvez Pinheiro, Amelia10 (AUTHOR), Cabrera, Mariela11 (AUTHOR), Hryb, Javier12 (AUTHOR), Nofal, Pedro13 (AUTHOR), Pestchanker, Claudia14 (AUTHOR), Vrech, Carlos15 (AUTHOR), Tavolini, Darío16 (AUTHOR), Tkachuk, Verónica7 (AUTHOR), Zanga, Gisela17 (AUTHOR), Marrodan, Mariano18 (AUTHOR), Ysrraelit, María Célica18 (AUTHOR) |
| المصدر: |
Neurological Sciences. Feb2024, Vol. 45 Issue 2, p379-389. 11p. |
| مصطلحات موضوعية: |
*COVID-19 vaccines, *BREAKTHROUGH infections, *COVID-19, *MULTIPLE sclerosis, *SARS-CoV-2 |
| مصطلحات جغرافية: |
ARGENTINA |
| مستخلص: |
We aimed to evaluate the incidence of SARS-CoV-2 breakthrough infection of SARS-CoV-2 vaccines in people with MS (PwMS) on high-efficacy disease-modifying therapies (HET) included in the national MS registry in Argentina (RelevarEM). Methods: Non-interventional, retrospective cohort study that collected information directly from RelevarEM. Adult PwMS who had been treated for at least 6 months with a HET (ocrelizumab, natalizumab, alemtuzumab, cladribine) who had received at least two doses of SARS-CoV-2 vaccines available in Argentina were included. Full course of vaccination was considered after the second dose of the corresponding vaccines. Cumulative incidence of SARS-CoV-2 infection was reported for the whole cohort by Kaplan–Meier survival curves (which is expressed in percentage) as well as incidence density (which is expressed per 10.000 patients/day with 95% CI). Results: Two hundred twenty-eight PwMS were included. Most frequent first and second dose received was AstraZeneca vaccine, followed by Sputnik vaccine. Most frequent HETs used in included patients were cladribine in 79 (34.8%). We found an incidence density of breakthrough COVID-19 infection of 3.5 × 10.000 patients/day (95% CI 2.3–6.7) after vaccination in Argentina. We described the incidence rate after vaccination for every HET used, it being significantly higher for ocrelizumab compared with other HETs (p = 0.005). Only five patients presented a relapse during the follow-up period with no differences regarding the pre-vaccination period. Conclusions: We found an incidence density of breakthrough COVID-19 infection of 3.5 × 10.000 patients/day (95% CI 2.3–6.7) after vaccination in Argentina. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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