Melatonin Secretion in Normal Pressure Hydrocephalus After Cerebral Aneurysm Rupture
| العنوان: | Melatonin Secretion in Normal Pressure Hydrocephalus After Cerebral Aneurysm Rupture |
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| المؤلفون: | Hideaki Iwasa, Shigeo Mori, Kazuko Fujimoto, Koichiro Kawashima, Toshio Masuzawa, Naoshi Yamada, Norikazu Kurokawa |
| المصدر: | Neurologia medico-chirurgica. 31:490-497 |
| بيانات النشر: | Japan Neurosurgical Society, 1991. |
| سنة النشر: | 1991 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, Light, Urology, Eye, Pineal Gland, Melatonin, Normal pressure hydrocephalus, medicine, Humans, Dilated third ventricle, Circadian rhythm, Melatonin secretion, Cerebral Hemorrhage, Rupture, Spontaneous, business.industry, Intracranial Aneurysm, Radioimmunoassay, Venous blood, Middle Aged, medicine.disease, Cerebrospinal Fluid Shunts, Hydrocephalus, Normal Pressure, Circadian Rhythm, Anesthesia, Female, Surgery, Neurology (clinical), business, Cerebral aneurysm rupture, medicine.drug |
| الوصف: | Melatonin (MLT) secretion was examined in six normal pressure hydrocephalus (NPH) patients before and after ventriculoperitoneal (VP) shunt surgery. Ten healthy subjects were used as controls. Venous blood samples were taken daily at 2 p.m., 8 p.m., 2 a.m., and 8 a.m. Radioimmunoassay of MLT used a new specific antiserum and separation method achieving low cross-reactivity and high-efficiency MLT separation. Plasma levels in the control group at 2 p.m. and 2 a.m. were significantly different, showing diurnal rhythm (DR). The patients' MLT levels before VP shunt were significantly lower than control levels and the DR was absent. Postoperatively, the values were significantly different from preoperative values only at 2 a.m., but the DR reappeared. Thus, in NPH, VP shunt surgery improved the melatonin DR, probably through normalization of the dilated third ventricle. |
| تدمد: | 1349-8029 0470-8105 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa43e4255a4be06f442df23a2632a06Test https://doi.org/10.2176/nmc.31.490Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4fa43e4255a4be06f442df23a2632a06 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13498029 04708105 |
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