Potential structural trait markers of depression in the form of alterations in the structures of subcortical nuclei and structural covariance network properties
| العنوان: | Potential structural trait markers of depression in the form of alterations in the structures of subcortical nuclei and structural covariance network properties |
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| المؤلفون: | Xiang Wang, Jiayue He, Daifeng Dong, Yali Jiang, Chuting Li, Yidian Gao, Xiaoqiang Sun, Shuqiao Yao, Haofei Zhao, Chang Cheng, Ge Xiong, Xue Zhong |
| المصدر: | NeuroImage : Clinical NeuroImage: Clinical, Vol 32, Iss, Pp 102871-(2021) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Structural covariance network, Cognitive Neuroscience, Thalamus, Computer applications to medicine. Medical informatics, R858-859.7, Major depressive disorder, Biology, urologic and male genital diseases, Remitted depression, medicine, Humans, Radiology, Nuclear Medicine and imaging, Gray Matter, RC346-429, Depression (differential diagnoses), Cerebral Cortex, Subcortical volume, Depressive Disorder, Major, Depression, Brain, Cognition, Regular Article, Left pulvinar, medicine.disease, bacterial infections and mycoses, State-independent alteration, Subcortical gray matter, Magnetic Resonance Imaging, female genital diseases and pregnancy complications, Neurology, nervous system, Structural covariance, Trait, Neurology (clinical), Neurology. Diseases of the nervous system, Neuroscience |
| الوصف: | Highlights • Reduced GMV in the left pallidum and PuA of thalamus were trait-like in MDD. • Reduced GMV in the right pallidum and VL of thalamus were state-dependent. • Altered topological properties of subcortical SCNs show trait-like features. It has been proposed recently that major depressive disorder (MDD) could represent an adaptation to conserve energy after the perceived loss of an investment in a vital source, such as group identity, personal assets, or relationships. Energy conserving behaviors associated with MDD may form a persistent marker in brain regions and networks involved in cognition and emotion regulation. In this study, we examined whether subcortical regions and volume-based structural covariance networks (SCNs) have state-independent alterations (trait markers). First-episode drug-naïve currently depressed (cMDD) patients (N = 131), remitted MDD (RD) patients (N = 67), and healthy controls (HCs, N = 235) underwent structural magnetic resonance imaging (MRI). Subcortical gray matter volumes (GMVs) were calculated in FreeSurfer software, and group differences in GMVs and SCN were analyzed. Compared to HCs, major findings were decreased GMVs of left pallidum and pulvinar anterior of thalamus in the cMDD and RD groups, indicative of a trait marker. Relative to HCs, subcortical SCNs of both cMDD and RD patients were found to have reduced small-world-ness and path length, which together may represent a trait-like topological feature of depression. In sum, the left pallidum, left pulvinar anterior of thalamus volumetric alterations may represent trait marker and reduced small-world-ness, path length may represent trait-like topological feature of MDD. |
| تدمد: | 2213-1582 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7efa94a50c8533fb7604cdd7a300edTest https://pubmed.ncbi.nlm.nih.gov/34749291Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4f7efa94a50c8533fb7604cdd7a300ed |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22131582 |
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