دورية أكاديمية
Increased functional activity, bottom-up and intrinsic effective connectivity in autism
| العنوان: | Increased functional activity, bottom-up and intrinsic effective connectivity in autism |
|---|---|
| المؤلفون: | Randeniya, R., Vilares, I., Mattingley, J.B., Garrido, M.I. |
| المصدر: | Neuroimage Clin |
| بيانات النشر: | Elsevier Elsevier BV |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Regular Article, psy |
| الوصف: | Sensory perceptual alterations such as sensory sensitivities in autism have been proposed to be caused by differences in sensory observation (Likelihood) or in forming models of the environment (Prior), which result in an increase in bottom-up information flow relative to top-down control. To investigate this conjecture, we had autistic individuals (AS) and neurotypicals (NT) perform a decision-under-uncertainty paradigm while undergoing functional magnetic resonance imaging (fMRI). There were no group differences in task performance and in Prior and Likelihood representations in brain activity. However, there were significant group differences in overall task activity, with the AS group showing significantly greater activation in the bilateral precuneus, mid-occipital gyrus, cuneus, superior frontal gyrus (SFG) and left putamen relative to the NT group. Further, when pooling the data across both groups, we found that those with higher AQ scores showed greater activity in the left cuneus and precuneus. Effective connectivity analysis using dynamic causal modelling (DCM) revealed that group differences in BOLD signals were underpinned by increased activity within sensory regions and a net increase in bottom-up connectivity from the occipital region to the precuneus and the left SFG. These findings support the hypothesis of increased bottom-up information flow in autism during sensory learning tasks. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791168Test/ |
| الإتاحة: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791168Test/ |
| حقوق: | undefined |
| رقم الانضمام: | edsbas.7F757B89 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |