Pin1 levels are downregulated during ER stress in human neuroblastoma cells
| العنوان: | Pin1 levels are downregulated during ER stress in human neuroblastoma cells |
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| المؤلفون: | Adee J. Bodewes, Frank Baas, Rob Zwart, Wiep Scheper, Jeroen J.M. Hoozemans, Onno C. Meijer, Yolanda S. Kap |
| المساهمون: | Public and occupational health, Amsterdam Neuroscience, Human Genetics, Neurology, Genome Analysis, Pathology, Human genetics, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, Amsterdam Neuroscience - Neurodegeneration, CCA - Target Discovery & Preclinial Therapy Development, CCA - Clinical Therapy Development |
| المصدر: | Neurogenetics, 8(1), 21-27. Springer Verlag Neurogenetics, 8(1), 21-7. Springer Verlag Kap, Y S, Hoozemans, J J M, Bodewes, A J, Zwart, R, Meijer, O C, Baas, F & Scheper, W 2007, ' Pin1 levels are downregulated during ER stress in human neuroblastoma cells ', Neurogenetics, vol. 8, no. 1, pp. 21-7 . https://doi.org/10.1007/s10048-006-0060-2Test |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | medicine.medical_specialty, DNA, Complementary, Down-Regulation, Endoplasmic Reticulum, Polymerase Chain Reaction, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Mice, Neuroblastoma, Downregulation and upregulation, Stress, Physiological, Internal medicine, Cell Line, Tumor, Consensus Sequence, Genetics, medicine, Animals, Humans, RNA, Messenger, RNA, Neoplasm, NIMA-Interacting Peptidylprolyl Isomerase, Genetics (clinical), Peptidylprolyl isomerase, Regulation of gene expression, Base Sequence, Chemistry, Endoplasmic reticulum, Tunicamycin, Peptidylprolyl Isomerase, Cell biology, Endocrinology, Gene Expression Regulation, Unfolded protein response, PIN1, Plasmids |
| الوصف: | Previously, we showed that pretangle neurons in Alzheimer's disease (AD) brain display unfolded protein stress in the endoplasmic reticulum (ER). Others showed that the peptidylprolyl isomerase Pin1 protects against tangle formation by facilitating tau dephosphorylation, corroborating with the lower expression of Pin1 observed in tangle-bearing neurons. In this study, we investigated Pin1 expression under ER stress conditions. We show that in human, but not mouse neuroblastoma cells, Pin1 is downregulated in response to ER stress, in accordance with the presence of an ER stress response element in the mouse, but not the human Pin1 gene. This study creates a starting point to investigate whether modulation of the ER stress response may prevent or delay tau pathology in AD. |
| اللغة: | English |
| تدمد: | 1364-6745 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf4ff9185635e93aabbc75798dfb9086Test https://doi.org/10.1007/s10048-006-0060-2Test |
| حقوق: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....bf4ff9185635e93aabbc75798dfb9086 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13646745 |
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