Two Ethnic Clusters with Huntington Disease in Israel: The Case of Mountain Jews and Karaites
| العنوان: | Two Ethnic Clusters with Huntington Disease in Israel: The Case of Mountain Jews and Karaites |
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| المؤلفون: | Nira Dangoor, Diana Paleacu, Ludmila Merkin, Avi Orr-Urtreger, Marieta Anca-Herschkovitch, Nir Giladi, Tanya Gurevich, Aya Bar David, Achinoam Faust-Socher, Meir Kestenbaum, Y. Balash, Jennifer Zitser, Tova Naiman, Yael Manor, Noit Inbar, Avner Thaler, Elissa L. Ash, Hertzel Shabtai, Alona Gad, Anat Bar-Shira, Chava Peretz |
| المصدر: | Neurodegenerative Diseases. 17:281-285 |
| بيانات النشر: | S. Karger AG, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Judaism, Population, Ethnic group, Disease, 030105 genetics & heredity, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Trinucleotide Repeats, Ethnicity, Humans, Medicine, Symptom onset, Israel, education, Huntingtin Protein, education.field_of_study, business.industry, Montreal Cognitive Assessment, Ashkenazi jews, Cross-Sectional Studies, Huntington Disease, Neurology, Jews, Cohort, Female, Neurology (clinical), business, 030217 neurology & neurosurgery, Demography |
| الوصف: | Background: Worldwide prevalence estimates of Huntington disease (HD) vary widely, with no reliable information regarding the Jewish population in Israel. Methods: This specialized tertiary single-center cross-sectional study assessed clinical, cognitive, and demographic characteristics of 84 HD patients who were treated at the Movement Disorder Unit of the Tel Aviv Medical Center, Israel. Results: Our cohort was composed of one-third Ashkenazi Jews, 27% Mountain Jews (Caucasus Jews), 18% Sephardi Jews, and 21% Karaites, with both Mountain Jews and Karaites over-represented compared to their relevant proportion in the population of the state of Israel, which is less than 1%. No between-group differences were detected regarding the number of CAG (cytosine-adenine-guanine) repeats, age at onset, disease duration, years from symptom onset to diagnosis, gender, years of education, Unified Huntington Disease Rating Scale scores, or the Montreal Cognitive Assessment scores. Conclusion: We detected clustering of HD among the population treated at our Medical Center, which has the only specialized HD clinic in the country, with a high percentage of HD among 2 relatively small subpopulations of Jews: Mountain Jews and Karaites. |
| تدمد: | 1660-2862 1660-2854 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51b605ca37eb51b813bc8b0ecc4c166aTest https://doi.org/10.1159/000479375Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....51b605ca37eb51b813bc8b0ecc4c166a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16602862 16602854 |
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