Orthostatic hypotension in Parkinson’s disease
| العنوان: | Orthostatic hypotension in Parkinson’s disease |
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| المؤلفون: | María Verónica Rey, Olivier Rascol, Anne Pavy-Le Traon, Santiago Perez-Lloret |
| المصدر: | Preprint del documento publicado en Neurodegenerative disease management Vol.3, Nro. 4, 2013 Repositorio Institucional (UCA) Pontificia Universidad Católica Argentina instacron:UCA |
| بيانات النشر: | Future Medicine Ltd, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Parkinson's disease, business.industry, FLUDROCORTISONA, Fludrocortisone, medicine.medical_treatment, Midodrine, Compression stockings, Disease, MEDICINA BASADA EN EVIDENCIA, medicine.disease, Review article, ENFERMEDAD DE PARKINSON, chemistry.chemical_compound, Orthostatic vital signs, chemistry, Anesthesia, medicine, HIPOTENSION ORTOSTATICA, Neurology (clinical), Droxidopa, business, EPIDEMIOLOGIA, medicine.drug |
| الوصف: | Fil: Pérez Lloret, Santiago. Universidad de Toulouse III. Hospital Universitario. Departamento de Farmacología Clínica y Neurociencia; Francia Fil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Laboratorio de Farmacología Clínica y Epidemiología; Argentina Fil: Rey, Verónica. Universidad de Toulouse III. Hospital Universitario. Departamento de Farmacología Clínica y Neurociencia; Francia Fil: Fil: Rey, Verónica. Pontificia Universidad Católica Argentina. Laboratorio de Farmacología Clínica y Epidemiología; Argentina Fil: Pavy-Le Traon, Anne. Universidad de Toulouse III. Hospital Universitario. Departamento de Farmacología Clínica y Neurociencia; Francia Fil: Rascol, Olivier. Universidad de Toulouse III. Hospital Universitario. Departamento de Farmacología Clínica y Neurociencia; Francia Abstract: Orthostatic hypotension (OH) is a frequent non-motor symptom in Parkinson’s Disease (PD) affecting between 22.9 and 38.4% of patients. OH is related in PD to increased risk of falls and possibly to cognitive dysfunction and increased mortality. These data emphasizes the importance of its prompt recognition and treatment. OH is related to pre-ganglionic and post-ganglionic adrenergic denervation, but other factors such as drugs, heat, meals or alcohol intake might also induce or aggravate it. Evidence about the efficacy and safety of pharmacological or non-pharmacological strategies for OH treatment in PD is weak. Non-pharmacological measures include liberal addition of salt to the diet, exercise, compression stocking or physical maneuvers. Severe cases may be treated with midodrine or fludrocortisone. Some results suggest that droxidopa and fipamezole might be effective treatments. We finish this review article by discussing the most important unanswered questions about PD-related OH, which might be the focus of future research |
| وصف الملف: | application/pdf |
| تدمد: | 1758-2032 1758-2024 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b6002dc257e0f54d8c793d1af51452fTest https://doi.org/10.2217/nmt.13.30Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8b6002dc257e0f54d8c793d1af51452f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17582032 17582024 |
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