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Polygenic risk scores for Alzheimer's disease in relation to cognitive change: A representative sample from the general population followed over 16 years.

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العنوان: Polygenic risk scores for Alzheimer's disease in relation to cognitive change: A representative sample from the general population followed over 16 years.
المؤلفون: Jenna Najar, Valgeir Thorvaldsson, Silke Kern, Johan Skoog, Margda Waern, Henrik Zetterberg, Kaj Blennow, Ingmar Skoog, Anna Zettergren
المصدر: Neurobiology of Disease, Vol 189, Iss , Pp 106357- (2023)
بيانات النشر: Elsevier, 2023.
سنة النشر: 2023
المجموعة: LCC:Neurosciences. Biological psychiatry. Neuropsychiatry
مصطلحات موضوعية: Cognition, Polygenic risk scores, Cognitive decline, APOE genotype, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
الوصف: Background: Polygenic risk scores for Alzheimer's disease (AD-PRSs) have been associated with cognition. However, few studies have examined the effect of AD-PRS beyond the APOE gene, and the influence of genetic variants related to level of cognitive ability (COG-PRS) on cognitive performance over time in the general older population. Method: A population-based sample of 965 individuals born in 1930, with genetic and standardized cognitive data on six psychometric tests (Thurstone's picture memory, immediate recall of 10 words, Block design, word fluency, figure identification, delayed recall of 12 items), were examined at age 70, 75, 79, and 85 years. Non-APOE AD-PRSs and COG-PRSs (P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1095-953X
العلاقة: http://www.sciencedirect.com/science/article/pii/S096999612300373XTest; https://doaj.org/toc/1095-953XTest
DOI: 10.1016/j.nbd.2023.106357
الوصول الحر: https://doaj.org/article/1d6f3371074c4d0896cd0e15861ae4d1Test
رقم الانضمام: edsdoj.1d6f3371074c4d0896cd0e15861ae4d1
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:1095953X
DOI:10.1016/j.nbd.2023.106357