دورية أكاديمية
Convergent imaging-transcriptomic evidence for disturbed iron homeostasis in Gilles de la Tourette syndrome
| العنوان: | Convergent imaging-transcriptomic evidence for disturbed iron homeostasis in Gilles de la Tourette syndrome |
|---|---|
| المؤلفون: | Kanaan, A., Yu, D., Metere, R., Schäfer, A., Schlumm, T., Bilgic, B., Anwander, A., Mathews, C., Scharf, J., Müller-Vahl, K., Möller, H. |
| المصدر: | Neurobiology of Disease |
| سنة النشر: | 2023 |
| المجموعة: | Max Planck Society: MPG.PuRe |
| الوصف: | Gilles de la Tourette syndrome (GTS) is a neuropsychiatric movement disorder with reported abnormalities in various neurotransmitter systems. Considering the integral role of iron in neurotransmitter synthesis and transport, it is hypothesized that iron exhibits a role in GTS pathophysiology. As a surrogate measure of brain iron, quantitative susceptibility mapping (QSM) was performed in 28 patients with GTS and 26 matched controls. Significant susceptibility reductions in the patient cohort, consistent with reduced local iron content, were obtained in subcortical regions known to be implicated in GTS. Regression analysis revealed a significant negative association of tic scores and striatal susceptibility. To interrogate genetic mechanisms that may drive these reductions, spatially specific relationships between susceptibility and gene-expression patterns extracted from the Allen Human Brain Atlas were assessed. Correlations in the striatum were enriched for excitatory, inhibitory, and modulatory neurochemical signaling mechanisms in the motor regions, mitochondrial processes driving ATP production and iron-sulfur cluster biogenesis in the executive subdivision, and phosphorylation-related mechanisms that affect receptor expression and long-term potentiation. This link between susceptibility reductions and normative transcriptional profiles suggests that disruptions in iron regulatory mechanisms are involved in GTS pathophysiology and may lead to pervasive abnormalities in mechanisms regulated by iron-containing enzymes. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf; application/vnd.openxmlformats-officedocument.spreadsheetml.sheet |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/37536382; http://hdl.handle.net/21.11116/0000-000D-2E34-6Test; http://hdl.handle.net/21.11116/0000-000D-9D97-8Test; http://hdl.handle.net/21.11116/0000-000D-9D98-7Test; http://hdl.handle.net/21.11116/0000-000F-049D-CTest; http://hdl.handle.net/21.11116/0000-000F-049E-BTest; http://hdl.handle.net/21.11116/0000-000F-049F-ATest; http://hdl.handle.net/21.11116/0000-000F-04A0-7Test |
| الإتاحة: | https://doi.org/10.1016/j.nbd.2023.106252Test http://hdl.handle.net/21.11116/0000-000D-2E34-6Test http://hdl.handle.net/21.11116/0000-000D-9D97-8Test http://hdl.handle.net/21.11116/0000-000D-9D98-7Test http://hdl.handle.net/21.11116/0000-000F-049D-CTest http://hdl.handle.net/21.11116/0000-000F-049E-BTest http://hdl.handle.net/21.11116/0000-000F-049F-ATest http://hdl.handle.net/21.11116/0000-000F-04A0-7Test |
| حقوق: | info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: | edsbas.FF5F118F |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |