Biomarkers in heart failure with preserved ejection fraction
| العنوان: | Biomarkers in heart failure with preserved ejection fraction |
|---|---|
| المؤلفون: | Wouter C. Meijers, A. R. Van der Velde, R. A. De Boer |
| المصدر: | Netherlands Heart Journal |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | NT-PROBNP, medicine.medical_specialty, BODY-COMPOSITION, medicine.drug_class, Developing heart, PHOSPHODIESTERASE-5 INHIBITION, Heart failure, Review Article, 030204 cardiovascular system & hematology, EXERCISE CAPACITY, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Diagnosis, medicine, Natriuretic peptide, I-PRESERVE, Natriuretic peptides, 030212 general & internal medicine, Ejection fraction, business.industry, DIASTOLIC DYSFUNCTION, Preserved ejection fraction, GROWTH-DIFFERENTIATION FACTOR-15, Prognosis, medicine.disease, Brain natriuretic peptide, PROGNOSTIC VALUE, Clinical trial, BRAIN NATRIURETIC PEPTIDE, CLINICAL STATUS, Cardiology, GDF15, Cardiology and Cardiovascular Medicine, Heart failure with preserved ejection fraction, business, Biomarkers |
| الوصف: | Biomarkers are widely used and studied in heart failure. Most studies have described the utility and performance of biomarkers in sub-studies of randomised clinical trials, where the vast majority of the patients suffered from heart failure with reduced ejection fraction (HFrEF), and not with preserved ejection fraction (HFpEF). As a result, there is a scarcity of data describing the levels, dynamics, clinical and biochemical correlates, and biology of biomarkers in patients suffering from HFpEF, whereas HFpEF is in fact a very frequent clinical entity. This article discusses the value of different biomarkers in HFpEF. We describe various aspects of natriuretic peptide measurements in HFpEF patients, with a focus on diagnosis, prognosis and the risk prediction of developing heart failure. Further, we will discuss several emerging biomarkers such as galectin-3 and suppression of tumorigenicity 2, and recently discovered ones such as growth differentiation factor-15 and syndecan-1. |
| تدمد: | 1876-6250 1568-5888 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf9471c3089b51424e6f8cb0034af9a8Test https://doi.org/10.1007/s12471-016-0817-7Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bf9471c3089b51424e6f8cb0034af9a8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18766250 15685888 |
|---|