MO664DYNAMIC ASSESSMENT OF INTERLEUKIN-6 DURING HEMODIALYSIS AND MORTALITY IN COVID 19
| العنوان: | MO664DYNAMIC ASSESSMENT OF INTERLEUKIN-6 DURING HEMODIALYSIS AND MORTALITY IN COVID 19 |
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| المؤلفون: | A. De Santos, Yohana Gil Giraldo, Borja Quiroga, A. Nuñez, Guillermina Barril, Martin Giorgi, Patricia Muñoz Ramos |
| المصدر: | Nephrology Dialysis Transplantation |
| بيانات النشر: | Oxford University Press, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Transplantation, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), biology, business.industry, medicine.medical_treatment, Systemic inflammation, chemistry.chemical_compound, Mini Orals (sorted by session), chemistry, Nephrology, Lactate dehydrogenase, Oxygen therapy, Internal medicine, medicine, biology.protein, Hemodialysis, medicine.symptom, Prospective cohort study, Interleukin 6, business, AcademicSubjects/MED00340, Dialysis. Extracorporeal dialysis: techniques and adequacy, Dialysis |
| الوصف: | Background and Aims The impact of the newly discovered severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease-19 (COVID-19) in hemodialysis patients remains poorly characterized. Some hemodialysis techniques reduce systemic inflammation but their impact on COVID-19 has not been addressed. The aim of this prospective study was to evaluate factors associated to mortality in COVID-19 hemodialysis patients, including the impact of reducing interleukin-6 using a cytokine adsorbent filter. Method This is a prospective single-center study including 16 hemodialysis patients with COVID-19. All were dialyzed using a polymethyl methacrylate (PMMA) filter. Interleukin-6 levels were obtained before and after the first admission hemodialysis session and at one week. Also we collected serum samples from 8 patients of our unit as controls: 4 in online hemodiafiltration (OLHDF) and 4 in high-flux hemodialysis Baseline comorbidities, laboratory values, chest X-ray and treatments were recorded and compared between survivors and non-survivors. Results Sixteen patients were included (13 males, mean age 72±15 years). Four patients (25%) died. Factors associated to mortality were dialysis vintage (p=0.01), the presence of infiltrates in chest X-ray (p=0.032), serum C-reactive protein (p=0.05) and lactate dehydrogenase (p=0.02) at one week, the requirement of oxygen therapy (p=0.02) and the use of anticoagulation (p Conclusion In hemodialysis COVID-19 patients, a positive balance of interleukin-6 during the session was associated to higher mortality. |
| اللغة: | English |
| تدمد: | 1460-2385 0931-0509 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f79c68ba33cfc37ff4b204269453231Test http://europepmc.org/articles/PMC8194986Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9f79c68ba33cfc37ff4b204269453231 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14602385 09310509 |
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