Tetanus Immunity in Neonates in a Developed Country
| العنوان: | Tetanus Immunity in Neonates in a Developed Country |
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| المؤلفون: | Ursula Wiedermann, Hanns Helmer, Elisabeth Förster-Waldl, Arnold Pollak, David C. Kasper, Michael Hayde, Andrea-Romana Prusa |
| المصدر: | Neonatology. 100:52-56 |
| بيانات النشر: | S. Karger AG, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Adult, Pediatrics, medicine.medical_specialty, Adolescent, MEDLINE, complex mixtures, Young Adult, Pregnancy, Immunity, Tetanus Toxoid, medicine, Humans, Young adult, Maternal-Fetal Exchange, Retrospective Studies, Tetanus, business.industry, Developed Countries, Vaccination, Infant, Newborn, Retrospective cohort study, biochemical phenomena, metabolism, and nutrition, Fetal Blood, medicine.disease, Antibodies, Bacterial, Pediatrics, Perinatology and Child Health, Immunology, Female, business, Immunity, Maternally-Acquired, Developed country, Developmental Biology |
| الوصف: | Objective: In consideration of comprehensive and well-established vaccination programmes in industrialized countries, it is expected that immunity against tetanus among expectant mothers and their offspring is complete. Our study evaluated seroprotection against tetanus among newborns in Austria, who may gain passive immunity by transplacental transfer of maternal tetanus antibody. Methods: Cord blood samples from 99 deliveries were analyzed for antibody concentration against tetanus toxoid by standardized ELISA. Results: 85/99 (85.8%) individuals presented with levels of tetanus immunity having a protective antibody concentration ≧0.1 IU/ml. 9/99 (9.1%) samples showed low seropositivity, while in 5/99 (5.1%) samples no tetanus antibodies could be detected. The median antibody concentration was 0.95 IU/ml. Conclusions: Our data provide evidence for a lack of adequate tetanus immunity in 14.2% of newborns delivered in an Austrian University Hospital. This investigation is emphasizing the importance of stringent regimens concerning prenatal vaccination care, even in countries with generalized immunization programs. If indicated, maternal immunization during pregnancy should be initiated for protection of newborns. |
| تدمد: | 1661-7819 1661-7800 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ee4cebdf232a0ec1b0bf0e92de3465Test https://doi.org/10.1159/000320637Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....12ee4cebdf232a0ec1b0bf0e92de3465 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16617819 16617800 |
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