يعرض 1 - 10 نتائج من 15 نتيجة بحث عن '"Lactate dehydrogenase"', وقت الاستعلام: 1.27s تنقيح النتائج
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    المصدر: Nederlands tijdschrift voor geneeskunde. 155(48)

    الوصف: Renal infarction is a condition not known to every physician, with often non-specific symptoms. The diagnosis is therefore often not considered initially in patients with acute abdominal pain.In a 77-year-old man a renal infarction was found by chance on a CT-scan performed performed for the evaluation of dyspnoea. Previously he had visited the emergency unit with abdominal pain, in retrospect attributable to renal infarction. A 61-year-old man initially labelled as suffering from gastro-enteritis was diagnosed correctly with renal infarction after his renal function deteriorated and the lactate dehydrogenase (LDH) activity increased.A raised serum creatinine level and LDH activity are classic indicators of renal infarction. In addition, most patients have haematuria. Typical wedge-shaped perfusion defects are visible on a CT-scan with intravenous contrast. Timely diagnosis of renal infarction is important both for the prevention of recurrence of thromboembolic complications and for potential revascularisation. The diagnosis of renal infarction should be included in the differential diagnosis in patients with acute abdominal pain.

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    المصدر: Nederlands tijdschrift voor geneeskunde. 142(45)

    الوصف: Two patients, one 76-year-old-man and one 79-year-old-woman with cardiovascular disease and one 36-year-old-man with Factor-V-Leiden deficiency (activated protein C-resistance) had abdominal pain and elevation of LDH levels. With abdominal CT scan kidney infarction was diagnosed. In two cases a selective kidney arteriography was performed to confirm the diagnosis. Treatment consisted of (re)starting anticoagulant therapy. In unexplained abdominal pain with insufficiently specific results of physical examination combined with a rapid rise of the LDH and sometimes of the serum creatinine, a kidney infarction should be considered in the differential diagnosis.

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    المصدر: Nederlands tijdschrift voor geneeskunde. 137(16)

    الوصف: To assess the prognostic significance of histological classification, grade and stage with regard to overall survival in patients with non-Hodgkin's lymphoma (NHL).Retrospective analysis.University Hospital St Radboud, Nijmegen.All consecutive 346 patients with NHL diagnosed in the period January 1978-December 1990 were included in this one-centre study. Recorded data included histological type according to the Kiel classification, histological grading according to the International Working Formulation (IWF), Ann Arbor stage, age, sex, tumour mass, number of extranodal sites, serum LDH and ESR. Grading according to the IWF was assessed retrospectively for those patients whose primary disease had been diagnosed before 1982. The observation period ended September 1st, 1991. Overall survival was calculated according to Kaplan-Meier. The significance of the prognostic parameters was studied using both univariate and multivariate stepwise regression analysis.There were 209 men and 137 women with a median age of 56 years (range 15-85). No initial treatment was given to 8% of the patients. After a median follow-up of 52 months, 179 patients (52%) had died; the calculated median survival time was 49 months. Patients with low-grade NHL had a significantly better short-term prognosis than the remaining patients. Related to clinical stage, only patients with stage I disease had distinctly longer survival times than those with more advanced disease. Multivariate analysis revealed serum LDH, age, stage and histological classification to be the most important independent prognostic variables.Even in multivariate analysis, histological classification and Ann Arbor stage have prognostic significance with regard to overall survival in patients with NHL. However, serum LDH levels proved to be the most important prognostic parameter.

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    المصدر: Nederlands tijdschrift voor geneeskunde. 133(10)

    الوصف: Of twelve patients with malignant histiocytosis admitted between 1974 and 1987, clinical symptoms, diagnostic procedures and the course of the disease were retrospectively evaluated. Predominant findings at physical examination were fever (11/12), splenomegaly (12/12), hepatomegaly (8/12), and lymphadenopathy (8/12). Laboratory findings included anaemia, leukocytopenia, thrombocytopenia, high lactate dehydrogenase, and jaundice. Positive diagnostic procedures included biopsies or aspirates of bone marrow (11/12), spleen (6/10), liver (7/9), lymph node (4/4), skin (1/2), lung (1/1) and blood (2/12). In seven patients treated with combination chemotherapy an average survival of 540 days was observed, while two long-term disease-free survivals were accomplished.

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