Substance P in the vagus nerve
| العنوان: | Substance P in the vagus nerve |
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| المؤلفون: | Fred Lembeck, A. C. Cuello, Rainer Gamse |
| المصدر: | Naunyn-Schmiedeberg's Archives of Pharmacology. 306:37-44 |
| بيانات النشر: | Springer Science and Business Media LLC, 1979. |
| سنة النشر: | 1979 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Efferent, Guinea Pigs, Substance P, In Vitro Techniques, Biology, Axonal Transport, Guinea pig, chemistry.chemical_compound, Internal medicine, medicine, Animals, Pharmacology, CATS, Histocytochemistry, Immunochemistry, Vagus Nerve, Radioimmunoassay, Nodose Ganglion, General Medicine, Rats, Vagus nerve, Endocrinology, nervous system, chemistry, Cats, Axoplasmic transport, Female, Rabbits, Colchicine |
| الوصف: | 1. The presence of immunoreactive substance P (I-SP) in the vagus nerve of 5 species was demonstrated by radioimmunoassay. Different amounts of SP per unit weight were found: Guinea pig > cat > rabbit, rat and cattle. 2. Infranodose ligations of the vagus nerve of cats and rabbits caused an accumulation of I-SP proximal but not distal to the ligation. The results obtained by radioimmunoassay and immunohistochemistry indicate a somatofugal axoplasmic transport of SP. 3. Double ligation experiments revealed that about 37% of I-SP of the cat vagus nerve are mobile. The transport rate of this mobile I-SP was found to be 170 mm per day. 4. Locally applied colchicine resulted in a similar accumulation of I-SP as after ligations. This is evidence favouring the involvement of microtubuli in the axoplasmic transport of SP. 5. Immunohistochemical data show that SP-fibers account for about 10% of the axons in the cat vagus nerve. Most of these SP-fibers seem to be unmyelinated. 6. Supranodose extracranial ligations of the cat vagus nerve led to an accumulation of I-SP on both sides of the ligature. Part of the SP-fibers are, therefore, afferent and their cell bodies are located in the nodose ganglion. The presence of efferent SP-fibers cannot be excluded. |
| تدمد: | 1432-1912 0028-1298 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51df7e1d103c4fac22e1df9fedd8fc07Test https://doi.org/10.1007/bf00515591Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....51df7e1d103c4fac22e1df9fedd8fc07 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14321912 00281298 |
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