The tumor suppressor p16INK4a prevents cell transformation through inhibition of c-Jun phosphorylation and AP-1 activity
| العنوان: | The tumor suppressor p16INK4a prevents cell transformation through inhibition of c-Jun phosphorylation and AP-1 activity |
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| المؤلفون: | Kwangseok Ko, Zigang Dong, Bu Young Choi, Feng Zhu, Bong Seok Kang, Yong-Yeon Cho, Wei-Ya Ma, Hong Seok Choi, Ann M. Bode, Svetlana P. Ermakova |
| المصدر: | Nature Structural & Molecular Biology. 12:699-707 |
| بيانات النشر: | Springer Science and Business Media LLC, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Models, Molecular, Skin Neoplasms, Genetic Vectors, Immunoblotting, Cell, Fluorescent Antibody Technique, Plasma protein binding, Biology, law.invention, Mice, Mitogen-Activated Protein Kinase 10, Structural Biology, law, Cell Line, Tumor, Two-Hybrid System Techniques, medicine, Animals, Humans, Neoplastic transformation, Phosphorylation, Melanoma, Molecular Biology, Cyclin-Dependent Kinase Inhibitor p16, Glutathione Transferase, Kinase, Cell biology, Transcription Factor AP-1, Transformation (genetics), Cell Transformation, Neoplastic, medicine.anatomical_structure, Cell culture, Suppressor, Protein Binding, Signal Transduction |
| الوصف: | Inactivation of the p16(INK4a) tumor suppressor protein is critical for the development of human cancers, including human melanoma. However, the molecular basis of the protein's inhibitory effect on cancer development is not clear. Here we investigated a possible mechanism for p16(INK4a) inhibition of neoplastic transformation and UV-induced skin cancer. We show that p16(INK4a) suppresses the activity of c-Jun N-terminal kinases (JNKs) and that it binds to the glycine-rich loop of the N-terminal domain of JNK3. Although p16(INK4a) does not affect the phosphorylation of JNKs, its interaction with JNK inhibits c-Jun phosphorylation induced by UV exposure. This, in turn, interferes with cell transformation promoted by the H-Ras-JNK-c-Jun-AP-1 signaling axis. |
| تدمد: | 1545-9985 1545-9993 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::415b34e1a345b06abe800948f0f36dbcTest https://doi.org/10.1038/nsmb960Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....415b34e1a345b06abe800948f0f36dbc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15459985 15459993 |
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