CD8(+) T cells in human autoimmune arthritis: the unusual suspects
| العنوان: | CD8(+) T cells in human autoimmune arthritis: the unusual suspects |
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| المؤلفون: | Femke van Wijk, Alessandra Petrelli |
| المصدر: | Nature Reviews. Rheumatology, 12(7), 421. Nature Publishing Group |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Genes, MHC Class I, Review, CD8-Positive T-Lymphocytes, T-Lymphocytes, Regulatory, Autoimmune Diseases, Pathogenesis, Arthritis, Rheumatoid, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Internal medicine, Journal Article, medicine, Cytotoxic T cell, Homeostasis, Humans, Autoantibodies, business.industry, medicine.disease, Phenotype, 030104 developmental biology, CTLA-4, HLA-B Antigens, Rheumatoid arthritis, Immunology, business, CD8, Biomarkers, 030215 immunology |
| الوصف: | CD8(+) T cells are key players in the body's defence against viral infections and cancer. To date, data on the role of CD8(+) T cells in autoimmune diseases have been scarce, especially when compared with the wealth of research on CD4(+) T cells. However, growing evidence suggests that CD8(+) T-cell homeostasis is impaired in human autoimmune diseases. The contribution of CD8(+) T cells to autoimmune arthritis is indicated by the close association of MHC class I polymorphisms with disease risk, as well as the correlation between CD8(+) T-cell phenotype and disease outcome. The heterogeneous phenotype, resistance to regulation and impaired regulatory function of CD8(+) T cells - especially at the target organ - might contribute to the persistence of autoimmune inflammation. Moreover, newly identified populations of tissue-resident CD8(+) T cells and their interaction with antigen-presenting cells might have a key role in disease pathology. In this Review, we assess the link between CD8(+) T cells, autoimmune arthritis and the basis of their homeostatic changes under inflammatory conditions. Improved insight into CD8(+) T cell-specific pathogenicity will be essential for a better understanding of autoimmune arthritis and the identification of new therapeutic targets. |
| وصف الملف: | image/pdf |
| تدمد: | 1759-4804 1759-4790 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ca20a0d7dd65ffa6622fd356fadff18Test https://pubmed.ncbi.nlm.nih.gov/27256711Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....2ca20a0d7dd65ffa6622fd356fadff18 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17594804 17594790 |
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