Glutathione S-transferases in kidney and urinary bladder tumors
| العنوان: | Glutathione S-transferases in kidney and urinary bladder tumors |
|---|---|
| المؤلفون: | Marija Matic, Jasmina Mimic-Oka, Tatjana Simic, Ana Savic-Radojevic, Marija Pljesa-Ercegovac |
| المصدر: | Nature Reviews Urology. 6:281-289 |
| بيانات النشر: | Springer Science and Business Media LLC, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Urology, Biology, urologic and male genital diseases, Isozyme, 03 medical and health sciences, GSTP1, chemistry.chemical_compound, 0302 clinical medicine, Downregulation and upregulation, Genotype, medicine, Humans, neoplasms, Carcinogen, Glutathione Transferase, 030304 developmental biology, 0303 health sciences, Kidney, Polymorphism, Genetic, Glutathione, medicine.disease, Kidney Neoplasms, female genital diseases and pregnancy complications, 3. Good health, medicine.anatomical_structure, Transitional cell carcinoma, Urinary Bladder Neoplasms, Biochemistry, chemistry, 030220 oncology & carcinogenesis, Cancer research |
| الوصف: | Exposure to potential carcinogens is an etiologic factor for renal cell carcinoma (RCC) and transitional cell carcinoma (TCC) of the urinary bladder. Cytosolic glutathione S-transferases (GSTs) are a superfamily of enzymes that protect normal cells by catalyzing conjugation reactions of electrophilic compounds, including carcinogens, to glutathione. Some GST enzymes possess antioxidant activity against hydroperoxides. The most well characterized classes have been named alpha (GSTA), mu (GSTM), pi (GSTP) and theta (GSTT); each of these classes contains several different isoenzymes. Several types of allelic variation have been identified within classes, with GSTM1-null, GSTT1-null and GSTP1-Ile105/Ile105 conferring impaired catalytic activity. The effects of GSTM1 and GSTT1 polymorphism on susceptibility to RCC depend on exposure to specific chemicals. Individuals with the GSTM1-null genotype carry a higher risk for TCC. The roles of GSTT1 polymorphism in TCC and GSTP1 polymorphisms in both cancers are still controversial. During kidney cancerization, expression of GSTA isoenzymes tends to decrease, which promotes the pro-oxidant environment necessary for RCC growth. In the malignant phenotype of TCC of the bladder, upregulation of various GST classes occurs. Upregulation of GSTT1 and GSTP1 might have important consequences for TCC growth by providing a reduced cellular environment and inhibition of apoptotic pathways. |
| تدمد: | 1759-4820 1759-4812 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc130c07d65094da584f1704a446696dTest https://doi.org/10.1038/nrurol.2009.49Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....bc130c07d65094da584f1704a446696d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17594820 17594812 |
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