التفاصيل البيبلوغرافية
| العنوان: |
The handwriting is on the wall: there will soon be a drug for AKI. |
| المؤلفون: |
Kellum, John A.1,2 kellum@pitt.edu, Fuhrman, Dana Y.1,2,3 |
| المصدر: |
Nature Reviews Nephrology. Feb2019, Vol. 15 Issue 2, p65-66. 2p. |
| مصطلحات موضوعية: |
*PALEOGRAPHY, *KIDNEY injuries, *HOSPITAL patients, *SALINE solutions |
| مستخلص: |
With many failures, a sense of helplessness has overshadowed the field of acute kidney injury (AKI). Publications in 2018 offer new hope: better drug targets, better end points and improved understanding of conditions that cause AKI and its complications bring promise that a drug will soon be available. The risk of acute kidney injury (AKI) and adverse kidney events in hospitalized patients can be reduced by using physiological solutions instead of saline for intravenous fluid therapy1,2.Strategies for the enrichment and subcategorization of patients with AKI who are most likely to benefit from specific treatments are now available5,8.New mechanisms and related drug targets, most notably related to mitochondrial dysfunction, have transformed the therapeutic landscape of AKI7-9.End points for use in trials of AKI therapies are now well defined1,2,5,10. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
