التفاصيل البيبلوغرافية
| العنوان: |
Harnessing invariant NKT cells in vaccination strategies. |
| المؤلفون: |
Cerundolo, Vincenzo, Silk, Jonathan D., Masri, S. Hajar, Salio, Mariolina |
| المصدر: |
Nature Reviews Immunology; Jan2009, Vol. 9 Issue 1, p28-38, 11p, 2 Diagrams, 3 Charts |
| مصطلحات موضوعية: |
KILLER cells, VACCINATION, IMMUNE response, IMMUNOLOGY, IMMUNE system, ANTIGENS, B cells, T cells |
| مستخلص: |
To optimize vaccination strategies, it is important to use protocols that can 'jump-start' immune responses by harnessing cells of the innate immune system to assist the expansion of antigen-specific B and T cells. In this Review, we discuss the evidence indicating that invariant natural killer T (iNKT) cells can positively modulate dendritic cells and B cells, and that their pharmacological activation in the presence of antigenic proteins can enhance antigen-specific B- and T-cell responses. In addition, we describe structural and kinetic analyses that assist in the design of optimal iNKT-cell agonists that could be used in the clinical setting as vaccine adjuvants. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
