Targeting JNK for therapeutic benefit: from junk to gold?
| العنوان: | Targeting JNK for therapeutic benefit: from junk to gold? |
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| المؤلفون: | Anthony M. Manning, Roger J. Davis |
| المصدر: | Nature Reviews Drug Discovery. 2:554-565 |
| بيانات النشر: | Springer Science and Business Media LLC, 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | Inflammation, Pharmacology, Drug discovery, Activator (genetics), Kinase, T-Lymphocytes, JNK Mitogen-Activated Protein Kinases, Neurodegenerative Diseases, General Medicine, Biology, Bioinformatics, Pathogenesis, Diabetes Mellitus, Type 2, Drug Design, Neoplasms, Drug Discovery, Gene expression, Animals, Humans, Phosphorylation, Obesity, Enzyme Inhibitors, Mitogen-Activated Protein Kinases, Transcription factor, Signal Transduction |
| الوصف: | The c-Jun NH(2)-terminal kinases (JNKs) phosphorylate and activate members of the activator protein-1 (AP-1) transcription factor family and other cellular factors implicated in regulating altered gene expression, cellular survival and proliferation in response to cytokines and growth factors, noxious stimuli and oncogenic transformation. Because these events are commonly associated with the pathogenesis of a number of human diseases, the potential of JNK inhibitors as therapeutics has attracted considerable interest. Here we discuss the evidence supporting the application of JNK inhibitors in inflammatory, vascular, neurodegenerative, metabolic and oncological diseases in humans, and describe the present status of drug discovery targeting JNK. |
| تدمد: | 1474-1784 1474-1776 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8022276dc2846ea33683b574acbfaa22Test https://doi.org/10.1038/nrd1132Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....8022276dc2846ea33683b574acbfaa22 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14741784 14741776 |
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