التفاصيل البيبلوغرافية
| العنوان: |
Molecular imaging by mass spectrometry--looking beyond classical histology. |
| المؤلفون: |
Schwamborn, Kristina1, Caprioli, Richard M.1 richard.m.caprioli@vanderbilt.edu |
| المصدر: |
Nature Reviews Cancer. Sep2010, Vol. 10 Issue 9, p639-646. 8p. |
| مصطلحات موضوعية: |
*MEDICAL imaging systems, *MASS spectrometry, *HISTOLOGY, *PROTEOMICS, *THERAPEUTICS, *PROTEINS, *ANIMALS, *DRUG design, *MICE, *TUMORS, *TREATMENT effectiveness |
| مستخلص: |
Imaging mass spectrometry (IMS) using matrix-assisted laser desorption ionization (MALDI) is a new and effective tool for molecular studies of complex biological samples such as tissue sections. As histological features remain intact throughout the analysis of a section, distribution maps of multiple analytes can be correlated with histological and clinical features. Spatial molecular arrangements can be assessed without the need for target-specific reagents, allowing the discovery of diagnostic and prognostic markers of different cancer types and enabling the determination of effective therapies. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
