التفاصيل البيبلوغرافية
| العنوان: |
Novel cancer immunotherapy agents with survival benefit: recent successes and next steps. |
| المؤلفون: |
Sharma, Padmanee, Wagner, Klaus, Wolchok, Jedd D., Allison, James P. |
| المصدر: |
Nature Reviews Cancer; Nov2011, Vol. 11 Issue 11, p805-812, 8p |
| مصطلحات موضوعية: |
IMMUNOTHERAPY, PROSTATE cancer treatment, MELANOMA treatment, IMMUNE response, TUMOR markers, THERAPEUTIC use of monoclonal antibodies, PROSTATE tumors treatment, THERAPEUTIC use of antineoplastic agents, RESEARCH, CLINICAL trials, MELANOMA, RESEARCH methodology, MONOCLONAL antibodies, ANTINEOPLASTIC agents, PROGNOSIS, EVALUATION research, MEDICAL cooperation, SKIN tumors, COMPARATIVE studies, RESEARCH funding, TISSUE extracts, PROSTATE tumors |
| الشركة/الكيان: |
UNITED States. Food & Drug Administration |
| مستخلص: |
The US Food and Drug Administration (FDA) recently approved two novel immunotherapy agents, sipuleucel-T and ipilimumab, which showed a survival benefit for patients with metastatic prostate cancer and melanoma, respectively. The mechanisms by which these agents provideclinical benefit are not completely understood. However, knowledge of these mechanisms will be crucial for probing human immune responses and tumour biology in order to understand what distinguishes responders from non-responders. The following next steps are necessary: first, the development of immune-monitoring strategies for the identification of relevant biomarkers; second, the establishment of guidelines for the assessment of clinical end points; and third, the evaluation of combination therapy strategies to improve clinical benefit. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
