SRF mediates activity-induced gene expression and synaptic plasticity but not neuronal viability
| العنوان: | SRF mediates activity-induced gene expression and synaptic plasticity but not neuronal viability |
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| المؤلفون: | Ying Shen, Sarah Sarsfield, Thomas Lemberger, Günther Schütz, Narendrakumar Ramanan, David D. Ginty, David J. Linden |
| المصدر: | Nature Neuroscience. 8:759-767 |
| بيانات النشر: | Springer Science and Business Media LLC, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Transcriptional Activation, Serum Response Factor, Cell Survival, MAP Kinase Signaling System, Long-Term Potentiation, Presynaptic Terminals, Nonsynaptic plasticity, Biology, CREB, Hippocampus, Synaptic Transmission, Mice, Organ Culture Techniques, Serum response factor, Metaplasticity, Animals, Cyclic AMP Response Element-Binding Protein, Genes, Immediate-Early, Neuronal memory allocation, Mice, Knockout, Neuronal Plasticity, Pyramidal Cells, General Neuroscience, Long-term potentiation, Mice, Mutant Strains, Synaptic fatigue, Gene Expression Regulation, Synaptic plasticity, biology.protein, Neuroscience, Signal Transduction |
| الوصف: | Synaptic activity-dependent gene expression is critical for certain forms of neuronal plasticity and survival in the mammalian nervous system, yet the mechanisms by which coordinated regulation of activity-induced genes supports neuronal function is unclear. Here, we show that deletion of serum response factor (SRF) in specific neuronal populations in adult mice results in profound deficits in activity-dependent immediate early gene expression, but components of upstream signaling pathways and cyclic AMP-response element binding protein (CREB)-dependent transactivation remain intact. Moreover, SRF-deficient CA1 pyramidal neurons show attenuation of long-term synaptic potentiation, a model for neuronal information storage. Furthermore, in contrast to the massive neurodegeneration seen in adult mice lacking CREB family members, SRF-deficient adult neurons show normal morphologies and basal excitatory synaptic transmission. These findings indicate that the transcriptional events underlying neuronal survival and plasticity are dissociable and that SRF plays a prominent role in use-dependent modification of synaptic strength in the adult brain. |
| تدمد: | 1546-1726 1097-6256 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b0ce1d74f20353f2b33045bb4ba98bbTest https://doi.org/10.1038/nn1462Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....9b0ce1d74f20353f2b33045bb4ba98bb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15461726 10976256 |
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