miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression
| العنوان: | miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression |
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| المؤلفون: | Akishi Onishi, Rikako Sanuki, Ryosuke Matsui, Toshiyuki Koyasu, Yuki Muranishi, Satoshi Watanabe, Shinji Uneo, Dai Watanabe, Yoan Cherasse, Toshihide Yamashita, Takahisa Furukawa, Rieko Muramatsu, Shoichi Irie, Mineo Kondo, Chieko Koike, Yoshihiro Urade |
| المصدر: | Nature Neuroscience. 14:1125-1134 |
| بيانات النشر: | Springer Science and Business Media LLC, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | RNA, Untranslated, Cell Survival, LIM-Homeodomain Proteins, Mice, Transgenic, Hippocampal formation, Biology, Hippocampus, Retina, Tissue Culture Techniques, Mice, chemistry.chemical_compound, In vivo, Electroretinography, In Situ Nick-End Labeling, Animals, RNA, Small Interfering, Mir 124a, Homeodomain Proteins, Neurons, Analysis of Variance, Tumor Suppressor Proteins, General Neuroscience, Dentate gyrus, Brain, Gene Expression Regulation, Developmental, Cell Differentiation, Retinal, Translation (biology), Embryo, Mammalian, Axons, Retinal Cones, MicroRNAs, Electroporation, Animals, Newborn, chemistry, Retinal Cone Photoreceptor Cells, Evoked Potentials, Visual, Neuroscience, Transcription Factors |
| الوصف: | MicroRNA-124a (miR-124a) is the most abundant microRNA expressed in the vertebrate CNS. Despite past investigations into the role of miR-124a, inconsistent results have left the in vivo function of miR-124a unclear. We examined the in vivo function of miR-124a by targeted disruption of Rncr3 (retinal non-coding RNA 3), the dominant source of miR-124a. Rncr3(-/-) mice exhibited abnormalities in the CNS, including small brain size, axonal mis-sprouting of dentate gyrus granule cells and retinal cone cell death. We found that Lhx2 is an in vivo target mRNA of miR-124a. We also observed that LHX2 downregulation by miR-124a is required for the prevention of apoptosis in the developing retina and proper axonal development of hippocampal neurons. These results suggest that miR-124a is essential for the maturation and survival of dentate gyrus neurons and retinal cones, as it represses Lhx2 translation. |
| تدمد: | 1546-1726 1097-6256 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98bdcc53c6b6b8a2ab8e478c9a293abdTest https://doi.org/10.1038/nn.2897Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....98bdcc53c6b6b8a2ab8e478c9a293abd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15461726 10976256 |
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