التفاصيل البيبلوغرافية
| العنوان: |
A chemical platform for improved induction of human iPSCs. |
| المؤلفون: |
Tongxiang Lin1, Ambasudhan, Rajesh1, Xu Yuan1, Wenlin Li1, Hilcove, Simon1, Abujarour, Ramzey1, Xiangyi Lin1, Hahm, Heung Sik1, Ergeng Hao2, Hayek, Alberto2, Sheng Ding1 sding@scripps.edu |
| المصدر: |
Nature Methods. Nov2009, Vol. 6 Issue 11, p805-808. 4p. 1 Color Photograph, 2 Graphs. |
| مصطلحات موضوعية: |
*STEM cells, *FIBROBLASTS, *SOMATIC cells, *MESSENGER RNA, *CONNECTIVE tissue cells |
| مستخلص: |
The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (200-fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, nonviral methods for reprogramming human somatic cells. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
