Hemolysis contributes to anemia during long-duration space flight
| العنوان: | Hemolysis contributes to anemia during long-duration space flight |
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| المؤلفون: | Trudel, Guy, Shahin, Nibras, Ramsay, Timothy, Laneuville, Odette, Louati, Hakim |
| المصدر: | Nature Medicine |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Adult, Male, Weightlessness, Anaemia, Diagnostic markers, Anemia, General Medicine, Middle Aged, Space Flight, Brief Communication, Hemolysis, General Biochemistry, Genetics and Molecular Biology, Astronauts, Humans, Female, Biomarkers |
| الوصف: | Anemia in astronauts has been noted since the first space missions, but the mechanisms contributing to anemia in space flight have remained unclear. Here, we show that space flight is associated with persistently increased levels of products of hemoglobin degradation, carbon monoxide in alveolar air and iron in serum, in 14 astronauts throughout their 6-month missions onboard the International Space Station. One year after landing, erythrocytic effects persisted, including increased levels of hemolysis, reticulocytosis and hemoglobin. These findings suggest that the destruction of red blood cells, termed hemolysis, is a primary effect of microgravity in space flight and support the hypothesis that the anemia associated with space flight is a hemolytic condition that should be considered in the screening and monitoring of both astronauts and space tourists. Biomarkers of red blood cell destruction were elevated in astronauts while on long-duration missions on the International Space Station, suggesting that hemolysis is a major contributor to space anemia. |
| تدمد: | 1546-170X 1078-8956 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8463a2174aeb416a3d813c775df8e9e9Test https://doi.org/10.1038/s41591-021-01637-7Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8463a2174aeb416a3d813c775df8e9e9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1546170X 10788956 |
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