NLRX1 promotes immediate IRF1-directed antiviral responses by limiting dsRNA-activated translational inhibition mediated by PKR
| العنوان: | NLRX1 promotes immediate IRF1-directed antiviral responses by limiting dsRNA-activated translational inhibition mediated by PKR |
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| المؤلفون: | Nathaniel J. Moorman, Hui Feng, Olga González-López, Stanley M. Lemon, Jenny P.-Y. Ting, Jinyao Mo, Jason K. Whitmire, Daisuke Yamane, Lola M. Reid, Ichiro Misumi, Joseph A. Duncan, Erik M. Lenarcic, Haitao Guo, Eliane Wauthier, David R. McGivern |
| المصدر: | Nature Immunology. 18:1299-1309 |
| بيانات النشر: | Springer Science and Business Media LLC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Chemistry, viruses, Immunology, Signal transducing adaptor protein, Protein kinase R, 3. Good health, Cell biology, 03 medical and health sciences, RNA silencing, 030104 developmental biology, 0302 clinical medicine, IRF1, Transcription (biology), Immunology and Allergy, IRF3, NLRX1, Transcription factor, 030215 immunology |
| الوصف: | NLRX1 is unique among the nucleotide-binding-domain and leucine-rich-repeat (NLR) proteins in its mitochondrial localization and ability to negatively regulate antiviral innate immunity dependent on the adaptors MAVS and STING. However, some studies have suggested a positive regulatory role for NLRX1 in inducing antiviral responses. We found that NLRX1 exerted opposing regulatory effects on viral activation of the transcription factors IRF1 and IRF3, which might potentially explain such contradictory results. Whereas NLRX1 suppressed MAVS-mediated activation of IRF3, it conversely facilitated virus-induced increases in IRF1 expression and thereby enhanced control of viral infection. NLRX1 had a minimal effect on the transcription of IRF1 mediated by the transcription factor NF-kB and regulated the abundance of IRF1 post-transcriptionally by preventing translational shutdown mediated by the double-stranded RNA (dsRNA)-activated kinase PKR and thereby allowed virus-induced increases in the abundance of IRF1 protein. |
| تدمد: | 1529-2916 1529-2908 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::9f3305a1acf56e01b3b0501777ff6cc0Test https://doi.org/10.1038/ni.3853Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........9f3305a1acf56e01b3b0501777ff6cc0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15292916 15292908 |
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