The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis
| العنوان: | The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis |
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| المؤلفون: | Costantino Pitzalis, Andrea Doni, Federica Tomay, Benedetta Savino, William Vermi, Roberta Carriero, Diego Morone, Rita Silva-Gomes, Irina N. Shalova, Matteo Stravalaci, Maria De Pizzol, Massimo Locati, Irene Mattiola, Alessandra Nerviani, Alberto Mantovani, Marie-Astrid Boutet, Subhra K. Biswas, Silvia Lonardi, Marina Sironi, Giovanna Mantovani, Tamara Gulic, Yunquin Lee, Barbara Bottazzi, Martina Molgora |
| المصدر: | Nature immunology Volume 20 Nature Immunology |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, POLARIZATION, Lymphocyte Activation, Inbred C57BL, Dexamethasone, Metastasis, Mice, 0302 clinical medicine, Lectins, Neoplasms, TUMOR-ASSOCIATED MACROPHAGES, PATTERN-RECOGNITION, BETA-SUBUNIT, DECTIN-1, RECEPTOR, CD20, IGE, IMMUNITY, FAMILY, Killer Cells, Immunology and Allergy, Macrophage, Neoplasm Metastasis, Receptor, Lipid raft, C-Type, Chemistry, Effector, Cell Differentiation, Primary tumor, Animals, Cell Lineage, Humans, Interleukin-4, Killer Cells, Natural, Lectins, C-Type, Macrophage Activation, Macrophages, Membrane Proteins, Mice, Inbred C57BL, Mice, Inbred NOD, Cell biology, Natural, BIOMEDICINA I ZDRAVSTVO. Temeljne medicinske znanosti, Immunology, 03 medical and health sciences, medicine, Interleukin 4, BIOMEDICINE AND HEALTHCARE. Basic Medical Sciences, medicine.disease, 030104 developmental biology, Tumor progression, Inbred NOD, 030215 immunology |
| الوصف: | The plasma membrane tetraspan molecule MS4A4A is selectively expressed by macrophage-lineage cells, but its function is unknown. Here we report that MS4A4A was restricted to murine and human mononuclear phagocytes and was induced during monocyte-to-macrophage differentiation in the presence of interleukin 4 or dexamethasone. Human MS4A4A was co-expressed with M2/M2-like molecules in subsets of normal tissue-resident macrophages, infiltrating macrophages from inflamed synovium and tumor-associated macrophages. MS4A4A interacted and colocalized with the β-glucan receptor dectin-1 in lipid rafts. In response to dectin-1 ligands, Ms4a4a-deficient macrophages showed defective signaling and defective production of effector molecules. In experimental models of tumor progression and metastasis, Ms4a4a deficiency in macrophages had no impact on primary tumor growth, but was essential for dectin-1-mediated activation of macrophages and natural killer (NK) cell–mediated metastasis control. Thus, MS4A4A is a tetraspan molecule selectively expressed in macrophages during differentiation and polarization, essential for dectin-1-dependent activation of NK cell–mediated resistance to metastasis. |
| وصف الملف: | application/pdf |
| تدمد: | 1529-2916 1529-2908 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6558a513383afa9768ca277f2a93c5f0Test https://doi.org/10.1038/s41590-019-0417-yTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6558a513383afa9768ca277f2a93c5f0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15292916 15292908 |
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