التفاصيل البيبلوغرافية
| العنوان: |
DNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retroviruses. |
| المؤلفون: |
Harris, Reuben S, Sheehy, Ann M, Craig, Heather M, Malim, Michael H, Neuberger, Michael S |
| المصدر: |
Nature Immunology. Jul2003, Vol. 4 Issue 7, p641. 3p. |
| مصطلحات موضوعية: |
*NATURAL immunity, *RETROVIRUSES, *DEAMINATION, *IMMUNOGLOBULINS, *DNA replication |
| مستخلص: |
A principle mechanism of innate immunity to retroviruses is achieved by direct deamination of retroviral first-strand cDNA at some stage during viral replication. DNA deamination targeted to endogenous immunoglobulin loci is used to trigger the diversification of antibodies in the adaptive immune system, DNA deamination targeted to retroviral DNA replication intermediates is used as an innate protection against foreign nucleic acid. The possibility of a mechanistic parallel between central defense pathways of the innate and adaptive immune systems was hinted at originally by the considerable similarity between APOBEC3G, a protein important for innate immunity to human immunodeficiency virus and activation-induced cytidine deaminase syndrome, a protein required for antibody gene diversification. |
| قاعدة البيانات: |
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