التفاصيل البيبلوغرافية
| العنوان: |
Regulation of tyrosine kinase activation and granule release through β-arrestin by CXCR1. |
| المؤلفون: |
Barlic, Jana, Andrews, Joseph D., Kelvin, Alyson A., Bosinger, Steven E., DeVries, Mark E., Xu, Luoling, Dobransky, Tomas, Feldman, Ross D., Ferguson, Stephen S. G., Kelvin, David J. |
| المصدر: |
Nature Immunology; Sep2000, Vol. 1 Issue 3, p227, 7p |
| مصطلحات موضوعية: |
CHEMOKINES, PROTEIN-tyrosine kinases, IMMUNE response |
| مستخلص: |
Chemoattractant-stimulated granule release from neutrophils, basophils and eosinophils is critical for the innate immune response against infectious bacteria. Interleukin 8 (IL-8) activation of the chemokine receptor CXCR1 was found to stimulate rapid formation of β-arrestin complexes with Hck or c-Fgr. Formation of β-arrestin?Hck complexes led to Hck activation and trafficking of the complexes to granule-rich regions. Granulocytes expressing a dominant-negative β-arrestin?mutant did not release granules or activate tyrosine kinases after IL-8 stimulation. Thus, β-arrestins regulate chemokine-induced granule exocytosis, indicating a broader role for β-arrestins in the regulation of cellular functions than was previously suspected. [ABSTRACT FROM AUTHOR] |
|
Copyright of Nature Immunology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
