المؤلفون: Brad R. Rosenberg, Thomas Tuschl, F. Nina Papavasiliou, Kenneth Lay, Eric L. Fritz, Aleksandra Mihailovic

المصدر: Nature Immunology. 14:749-755

مصطلحات موضوعية: Genetics, 0303 health sciences, Physiological function, biology, Immunology, Computational biology, Cytidine deaminase, 3. Good health, Transcriptome, 03 medical and health sciences, 0302 clinical medicine, Immunoglobulin class switching, 030220 oncology & carcinogenesis, microRNA, DNA methylation, Activation-induced (cytidine) deaminase, biology.protein, Immunology and Allergy, Antibody, 030304 developmental biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::419a7b3b3a47d90dc4c10d0662c4cb32Test
https://doi.org/10.1038/ni.2616Test

المؤلفون: Muneer G. Hasham, Kathy J. Snow, Jacquelyn Ames, Jane Maynard, Robert Y Wilpan, Benjamin L. King, Yishu He, Nina M Donghia, Eliot L. Coffey, Kevin D. Mills

المصدر: Nature immunology

مصطلحات موضوعية: Genome instability, Cell Survival, Immunology, Somatic hypermutation, Biology, Article, Genomic Instability, XRCC2, 03 medical and health sciences, 0302 clinical medicine, Cytidine Deaminase, medicine, Activation-induced (cytidine) deaminase, Immunology and Allergy, Humans, B cell, Cells, Cultured, 030304 developmental biology, Recombination, Genetic, 0303 health sciences, B-Lymphocytes, Reverse Transcriptase Polymerase Chain Reaction, Cell Cycle, DNA Breaks, Cytidine deaminase, Flow Cytometry, Molecular biology, 3. Good health, DNA-Binding Proteins, medicine.anatomical_structure, Immunoglobulin class switching, biology.protein, Homologous recombination, 030215 immunology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae0c1c946c2da3feeccce538bcef5f3fTest
http://europepmc.org/articles/PMC2930818Test

المؤلفون: Zhenming Xu, Paolo Casali, Egest J. Pone, Seok-Rae Park, Zsuzsanna Pal, Jinsong Zhang, Thach Mai, Ahmed A. Al-Qahtani, Hong Zan

المصدر: Park, SR; Zan, H; Pal, Z; Zhang, J; Al-Qahtani, A; Pone, EJ; et al.(2009). HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation. Nature Immunology, 10(5), 540-550. doi: 10.1038/ni.1725. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/07m6q9psTest

مصطلحات موضوعية: Regulation of gene expression, 0303 health sciences, Immunology, Germinal center, Somatic hypermutation, chemical and pharmacologic phenomena, Cytidine deaminase, Biology, Molecular biology, Conserved sequence, 03 medical and health sciences, 0302 clinical medicine, Immunoglobulin class switching, Activation-induced (cytidine) deaminase, biology.protein, Immunology and Allergy, Transcription factor, 030304 developmental biology, 030215 immunology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cad15d3bf135d6ab83c262040b7a434eTest
https://doi.org/10.1038/ni.1725Test

المؤلفون: Alexander Tarakhovsky, Elin Axelsson, Beatriz Cebolla, Maria Fischer, Meinrad Busslinger, Peter Bönelt, Martina Minnich, Hiromi Tagoh, Stephen L. Nutt, Markus Jaritz

المصدر: Nature immunology. 17(3)

مصطلحات موضوعية: 0301 basic medicine, Chromatin Immunoprecipitation, Immunology, Plasma Cells, Electrophoretic Mobility Shift Assay, Enzyme-Linked Immunosorbent Assay, Biology, Immunoglobulin secretion, Mass Spectrometry, Article, 03 medical and health sciences, Immunoglobulin kappa-Chains, Mice, Cell Migration Assays, Leukocyte, Cell Movement, Plasma cell differentiation, Gene expression, Activation-induced (cytidine) deaminase, Cell Adhesion, Immunology and Allergy, Animals, Humans, Enhancer, Transcription factor, B-Lymphocytes, Reverse Transcriptase Polymerase Chain Reaction, Sequence Analysis, RNA, High-Throughput Nucleotide Sequencing, Cell Differentiation, Cytidine deaminase, Sequence Analysis, DNA, Flow Cytometry, Molecular biology, 030104 developmental biology, HEK293 Cells, Gene Expression Regulation, Interferon Regulatory Factors, biology.protein, Immunoglobulin heavy chain, Positive Regulatory Domain I-Binding Factor 1, Immunoglobulin Heavy Chains, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b71f261dead2ed16dd0f086bedbee8bTest
https://pubmed.ncbi.nlm.nih.gov/26779602Test

المؤلفون: Alain Fischer, Anne Durandy, Hans D. Ochs, Wen I. Lee, Patrick Revy, Nadia Catalan, Leman Yel, Shigeaki Nonoyama, Geir Slupphaug, Hans E. Krokan, Kohsuke Imai, Bodil Kavli, Monique Forveille

المصدر: Nature Immunology. 4:1023-1028

مصطلحات موضوعية: Adult, Hyper IgM syndrome, Molecular Sequence Data, Immunology, Somatic hypermutation, Immunoglobulin Class Switch Recombination, DNA Glycosylases, Mice, chemistry.chemical_compound, Cytidine Deaminase, Activation-induced (cytidine) deaminase, medicine, Animals, Humans, Immune Complex Diseases, Point Mutation, Immunology and Allergy, Amino Acid Sequence, RNA, Messenger, Child, Uracil-DNA Glycosidase, N-Glycosyl Hydrolases, Genetics, Mice, Inbred BALB C, Base Sequence, biology, Reverse Transcriptase Polymerase Chain Reaction, Sequence Analysis, DNA, Cytidine deaminase, medicine.disease, Immunoglobulin Class Switching, Molecular biology, Gene Expression Regulation, Immunoglobulin M, chemistry, DNA glycosylase, Uracil-DNA glycosylase, biology.protein, Somatic Hypermutation, Immunoglobulin, Cytosine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec1c305504645a2f6a8cee6c67aa8b5Test
https://doi.org/10.1038/ni974Test

المؤلفون: Yasutoshi Agata, Melanie W. Quong, Cornelis Murre, Camil Elie Sayegh

المصدر: Nature Immunology. 4:586-593

مصطلحات موضوعية: Molecular Sequence Data, Transcription Factor 7-Like 1 Protein, Immunology, Biology, Lymphocyte Activation, TCF/LEF family, Gene Expression Regulation, Enzymologic, Mice, Enzyme activator, Transcription (biology), Cytidine Deaminase, Activation-induced (cytidine) deaminase, Animals, Immunology and Allergy, Regulation of gene expression, B-Lymphocytes, Base Sequence, Helix-Loop-Helix Motifs, Immunoglobulin Class Switching, Molecular biology, In vitro, DNA-Binding Proteins, Enzyme Activation, Immunoglobulin Isotypes, Mice, Inbred C57BL, Enhancer Elements, Genetic, Immunoglobulin class switching, biology.protein, Female, TCF Transcription Factors, Signal Transduction, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7c6909823428a92e21a2c1bd8729bfcTest
https://doi.org/10.1038/ni923Test

المؤلفون: Sidonia Fagarasan, Min Wei, Reiko Shinkura, Mikako Maruya, Yasuko Doi, Tasuku Honjo

المصدر: Nature immunology. 12(3)

مصطلحات موضوعية: Genotype, Immunology, Population, Somatic hypermutation, Biology, medicine.disease_cause, Article, Mice, Gene knockin, Cytidine Deaminase, medicine, Activation-induced (cytidine) deaminase, Immunology and Allergy, Mucosal defense, Animals, Homeostasis, Gene Knock-In Techniques, Intestinal Mucosa, education, education.field_of_study, Mutation, Cytidine deaminase, Intestines, biology.protein, Somatic Hypermutation, Immunoglobulin, Gut homeostasis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1848ad95826bb58f49556d8cc4df18dcTest
https://pubmed.ncbi.nlm.nih.gov/21321590Test

المؤلفون: Reiko Shinkura, Thinh Huy Tran, Keiichiro Suzuki, Mikiyo Nakata, Tasuku Honjo, Sidonia Fagarasan, Hitoshi Nagaoka, Nasim A. Begum

المصدر: Nature immunology. 11(2)

مصطلحات موضوعية: Immunology, Gene Expression, Mice, Cytidine Deaminase, Transcriptional regulation, Activation-induced (cytidine) deaminase, Silencer Elements, Transcriptional, Immunology and Allergy, Animals, Humans, E2F, Enhancer, Promoter Regions, Genetic, Transcription factor, Oligonucleotide Array Sequence Analysis, Genetics, B-Lymphocytes, biology, Genes, Immunoglobulin, Activator (genetics), Reverse Transcriptase Polymerase Chain Reaction, Gene Expression Profiling, Promoter, Cytidine deaminase, Oncogenes, Immunoglobulin Class Switching, Enhancer Elements, Genetic, Gene Expression Regulation, biology.protein, Mutagenesis, Site-Directed, Somatic Hypermutation, Immunoglobulin, Immunologic Memory

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf831b670dea91b37eab0b8e28bdcf61Test
https://pubmed.ncbi.nlm.nih.gov/20084065Test

المؤلفون: Jolanta Zaim, Andrzej M. Kierzek

المصدر: Nature immunology. 4(12)

مصطلحات موضوعية: Genetics, biology, Chemistry, APOBEC-1 Deaminase, Immunology, Sequence Homology, Domain (software engineering), Sequence homology, Cytidine Deaminase, Mutation (genetic algorithm), Mutation, Activation-induced (cytidine) deaminase, biology.protein, Escherichia coli, Immunology and Allergy, Amino Acid Sequence, Peptide sequence

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8fe8f07067a05cded74bb6f22a8bac6Test
https://pubmed.ncbi.nlm.nih.gov/12910268Test

المؤلفون: Said Aoufouchi, Claude-Agnès Reynaud, Ahmad Faili, Jean-Claude Weill

المصدر: Nature immunology. 4(7)

مصطلحات موضوعية: Genetics, biology, Genes, Immunoglobulin, Transcription, Genetic, DNA polymerase, Immunology, Deamination, Somatic hypermutation, Locus (genetics), Cytidine deaminase, DNA-Directed DNA Polymerase, Cytidine deamination, Cytidine Deaminase, biology.protein, Activation-induced (cytidine) deaminase, Immunology and Allergy, Animals, Humans, RNA Editing, Somatic Hypermutation, Immunoglobulin, Gene, DNA Damage

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddbc9cec47ab7b9147d11ed341c18674Test
https://pubmed.ncbi.nlm.nih.gov/12830138Test