التفاصيل البيبلوغرافية
| العنوان: |
Deep learning of cell spatial organizations identifies clinically relevant insights in tissue images. |
| المؤلفون: |
Wang, Shidan, Rong, Ruichen, Zhou, Qin, Yang, Donghan M., Zhang, Xinyi, Zhan, Xiaowei, Bishop, Justin, Chi, Zhikai, Wilhelm, Clare J., Zhang, Siyuan, Pickering, Curtis R., Kris, Mark G., Minna, John, Xie, Yang, Xiao, Guanghua |
| المصدر: |
Nature Communications; 12/11/2023, Vol. 14 Issue 1, p1-15, 15p |
| مصطلحات موضوعية: |
DEEP learning, CELL communication, PROTEIN-tyrosine kinase inhibitors, IMAGE analysis |
| مستخلص: |
Recent advancements in tissue imaging techniques have facilitated the visualization and identification of various cell types within physiological and pathological contexts. Despite the emergence of cell-cell interaction studies, there is a lack of methods for evaluating individual spatial interactions. In this study, we introduce Ceograph, a cell spatial organization-based graph convolutional network designed to analyze cell spatial organization (for example,. the cell spatial distribution, morphology, proximity, and interactions) derived from pathology images. Ceograph identifies key cell spatial organization features by accurately predicting their influence on patient clinical outcomes. In patients with oral potentially malignant disorders, our model highlights reduced structural concordance and increased closeness in epithelial substrata as driving features for an elevated risk of malignant transformation. In lung cancer patients, Ceograph detects elongated tumor nuclei and diminished stroma-stroma closeness as biomarkers for insensitivity to EGFR tyrosine kinase inhibitors. With its potential to predict various clinical outcomes, Ceograph offers a deeper understanding of biological processes and supports the development of personalized therapeutic strategies. Cell spatial organization in tissue provides essential insights into diseases. Here, the authors show Ceograph, a graph convolutional network, for the analysis of pathology images to predict patient outcomes, highlighting cellular markers to guide personalized treatments and enhance biological understanding. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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