mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4

التفاصيل البيبلوغرافية
العنوان:	mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4
المؤلفون:	Perrine Castets, Nathalie Rion, Marine Théodore, Denis Falcetta, Shuo Lin, Markus Reischl, Franziska Wild, Laurent Guérard, Christopher Eickhorst, Marielle Brockhoff, Maitea Guridi, Chikwendu Ibebunjo, Joseph Cruz, Michael Sinnreich, Rüdiger Rudolf, David J. Glass, Markus A. Rüegg
المصدر:	Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
بيانات النشر:	Nature Portfolio, 2019.
سنة النشر:	2019
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	Denervation leads to muscle atrophy and neuromuscular endplate remodeling. Here, the authors show that a balanced activation of mTORC1 contributes to the dynamic regulation of autophagic flux in denervated muscle and that activation of PKB/Akt promotes the nuclear import of HDAC4, which is essential for endplate maintenance upon nerve injury
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
العلاقة:	https://doaj.org/toc/2041-1723Test
DOI:	10.1038/s41467-019-11227-4
الوصول الحر:	https://doaj.org/article/ad2327d58d6a49b7a54e496210a1a5f2Test
رقم الانضمام:	edsdoj.2327d58d6a49b7a54e496210a1a5f2
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/s41467-019-11227-4